AIF1 antibody

Principal name

AIF1 antibody

Alternative names for AIF1 antibody

AIF-1, Protein G1, IBA1, Allograft inflammatory factor 1, Ionized Calcium-Binding Adapter Molecule 1

SwissProt ID

O70200 (Mouse), P55008 (Human), P55009 (Rat), P81076 (Pig), Q9BDK2 (Bovin)

Gene ID

199 (AIF1), 11629 (Aif1), 29427

Available reactivities

Hu (Human), Por (Porcine), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Fu (Fungi), Gt (Goat), Mky (Monkey), Pl (Plant), Prim (Primate), Rb (Rabbit), Bear, Hst (Hamster), Ms (Mouse)

Available hosts

Mouse, Goat, Rabbit

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Selected product citations ‐ of AP08912PU-N

1. Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Chepkova AN, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016 Feb;139(Pt 2):509-25. doi: 10.1093/brain/awv355. Epub 2015 Dec 10. PubMed PMID: 26657517. 
2. Herring, A;Münster, Y;Akkaya, T;Moghaddam, S;Deinsberger, K;Meyer, J;Zahel, J;Sanchez-Mendoza, E;Wang, Y;Hermann, DM;Arzberger, T;Teuber-Hanselmann, S;Keyvani, K. Kallikrein-8 inhibition attenuates Alzheimer's pathology in mice. Alzheimers Dement 2016.  PubMed PMID: 27327541.

Background of AIF1 antibody

AIF1(Allograft inflammatory factor 1), also known as IRT-1, is a protein that in humans is encoded by the AIF1 gene. This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. The gene expresses three transcripts.Using in vitro binding and coimmunoprecipitation assays, Autieri et al. (2003) determined that AIF1 interacts with actin. In unstimulated VSMCs, AIF1 colocalized with F-actin, but translocated to lamellipodia upon PDGF stimulation. VSMCs stably transduced with AIF1 retrovirus migrated 2.6-fold more rapidly in response to PDGF than control cells. AIF1 colocalized with RAC1, and AIF1-transduced VSMCs showed a constitutive and enhanced activation of RAC1. Autieri et al. (2003) concluded that AIF1 binds and polymerizes F-actin and regulates RAC1 activity and VSMC migration.

General readings

Kelemen S.E., et al (2005) Am. J. Pathol. 167:619-626.
Schulze J.O., et al. (2008) FEBS J. 275:4627-4640.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AIF1 antibody

  Rabbit polyclonal antibody to AIF1 (allograft inflammatory factor 1)  
Iba1 antibody detects Iba1 protein by western blot analysis. A. 30 ug THP-1 whole cell lysate/extract. B. 30 ug HL-60 whole cell lysate/extract. 15 % SDS-PAGE. Iba1 antibody (TA308592) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIF1 (Isoform 1 and 3) (C-term) antibody

  Goat Polyclonal Antibody against AIF1  
TA302786 (0.5 ug/ml) staining of Rat Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Por, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIF1 (Isoform 3) antibody

  Goat Polyclonal Antibody against AIF1 (Internal Region)  
Anti-AIF1 (0.5µg/ml) staining of Human Frontal Cortex lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIF1 (Isoform 1 and 3) antibody

  Goat Polyclonal Antibody against AIF1 (C-terminal)  
TA303109 (1µg/ml) staining of Human Lymph Node lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIF1 antibody

  Anti-AIF1 Rabbit Polyclonal Antibody  
Western blot analysis of Mouse kidney tissue using TA323136(AIF1 Antibody) at dilution 1/500 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIF1 antibody

  Anti-AIF1 Rabbit Polyclonal Antibody  
Immunohistochemistry of paraffin-embedded Human gastic cancer tissue using TA323137(AIF1 Antibody)(left image) at dilution 1/50, the image on the right is treated with the fusion protein.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIF1 (138-148) antibody

AP08793PU-N AIF1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Placenta tissue at 2.5 µg/ml. Goat IgG Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Fu, Gt, Hu, Mky, Pl, Por, Prim, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AIF1 (149-161) antibody

Formalin-Fixed, Paraffin-Embedded Human Lung staining using AP08912PU-N AIF1 Antibody at 5 µg/ml after heat-induced antigen retrieval. Goat IgG Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Gt, Hst, Hu, Mky, Ms, Platypus, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AIF1 antibody

Western Blot Analysis using of ant AIF1 cat# AP20480PU-N on MCF7 cells (lane 1), Mouse liver tissue lysate (lane 2) and rat heart tissue lysate (land 3) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

AIF1 (N-term) antibody

AIF1 antibody (N-term) (Cat. #AP50122PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AIF1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AIF1 antibody

BM4114 AIF1 antibody staining of Paraffin Human Spleen Section. Mouse IgG2b 1022-5 Aff - Purified Hu, Por, Rt P
0.2 mg / €570.00
  Acris Antibodies GmbH

AIF1 antibody

Figure 1. BM4114B AIF1 antibody staining of Human Spleen Paraffin Section. Mouse IgG2b 1022-5 Biotin Hu, Por, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

AIF1 antibody

AIF1 Mouse IgG2b 1022-5 FITC Hu, Por, Rt F, P
0.2 mg / €570.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

AIF1 - human gene knockout kit via CRISPR

AIF1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AIF1 - human gene knockout kit via CRISPR

AIF1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AIF1 - human gene knockout kit via CRISPR

AIF1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AIF1 - human gene knockout kit via CRISPR

AIF1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aif1 - mouse gene knockout kit via CRISPR

Aif1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Aif1 - mouse gene knockout kit via CRISPR

Aif1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aif1 - mouse gene knockout kit via CRISPR

Aif1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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