AIM2 antibody
Principal name
AIM2 antibody
Alternative names for AIM2 antibody
Absent in melanoma 2, Interferon-inducible protein AIM2
Ncbi ID
9606, NP_004824, NP_004824.1, AAH10940.1, NM_001013779, NM_004833
Available reactivities
Available hosts
Available applications
ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP)
Background of AIM2 antibody
AIM2 (Absent in Melanoma-2) is an interferon-inducible cytosolic protein of the IFI20X/IFI16 family, which is essential for an effective inte immune response. It plays a key role in the defence against bacterial and viral D. AIM2 is essential for inflammasome activation in response to Francisella tularensis, vaccinia virus and Listeria monocytogenes (Ferndes-Alnemri T et al, 2009). It recognizes cytosolic dsD and forms a Caspase-1 activating inflammasome with ASC (apoptosis-associated speck-like protein containing a CARD) protein (Jones JW et al, 2010). The C-termil HIN domain binds double stranded D and acts as a cytosolic dsD sensor. The pyrin domain allows for the association with ASC and formation of the inflammasome. Formation of the AIM2 inflammsome leads to the processing and release of mature IL-1Beta and IL-18 and host cell death (Hornung V et al, 2009). AIM2 plays a role in tumorigenic reversion and may control cell proliferation. It may repress NF-kappaB transcriptiol activity.AIM2 antigen is expressed in a wide variety of tumor types, including neuroectodermal tumors, as well as breast, ovarian and colon carcinomas. AIM2 induces the expression of invasion-associated genes such as VIM and MCAM, whereas downregulates ANXA10 and CDH1. AIM2 reduces breast cancer proliferation and mammary tumor growth and shows a high frequency of frameshift mutations in microsatellite unstable (MSI-H) gastric, endometrial and colorectal cancers.Defects in AIM2expression within immune cells contribute to increased susceptibility to lupus. AIM2 could be used as a tumor antigen target for monitoring vaccine trials or to develop antigen specific active immunotherapy for glioma patients. It may serve as a potential therapeutic gene for future development of AIM2-based gene therapy for human breast cancer (Liu G et al, 2004).
General readings
Woerner,S.M., (2007) Genes Chromosomes Cancer 46 (12), 1080-1089






















Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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AP22454PU-N | AIM2 (C-term) antibody |
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Goat | Aff - Purified | Hu | E, P, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
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Acris recommends this product for Western blotting. |
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TA314913 | AIM2 antibody |
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Rabbit polyclonal anti-AIM2 antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA314914 | AIM2 antibody |
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Rabbit polyclonal anti-CSRL1 antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, ICC/IF, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA324972 | AIM2 antibody |
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Mouse monoclonal AIM2 Antibody | |||||||
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Mouse | IgM | 812CT9.2.2.1 | Purified | Hu | WB |
0.4 ml /
€410.00
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OriGene Technologies, Inc. | |||||||
TA326327 | AIM2 antibody |
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Goat Anti-AIM2 Antibody | |||||||
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Goat | Aff - Purified | Hu | WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA328184 | AIM2 antibody |
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Mouse monoclonal anti-AIM2 antibody(Ascites) | |||||||
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Mouse | IgM | 812CT9.2.2.1 | Purified | Hu | WB |
0.1 ml /
€410.00
|
OriGene Technologies, Inc. | |||||||
TA337162 | AIM2 antibody |
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Mouse Monoclonal AIM2 Antibody (10M5G5) | |||||||
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Mouse | IgG2a | 10M5G5 | Purified | Hu | WB |
0.1 mg /
€416.00
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OriGene Technologies, Inc. | |||||||
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TA337163 | AIM2 antibody |
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Mouse Monoclonal AIM2 Antibody (10M2B3) | |||||||
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Mouse | IgG2a | 10M2B3 | Purified | Hu | WB |
0.1 mg /
€416.00
|
OriGene Technologies, Inc. | |||||||
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TA339684 | AIM2 antibody |
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Rabbit Polyclonal Anti-AIM2 Antibody | |||||||
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Rabbit | IgG | Purified | Eq, Hu, Ms, Rt, Ze | WB |
50 µg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA349676 | AIM2 antibody |
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Rabbit Polyclonal Anti-AIM2 Antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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AP50126PU-N | AIM2 (N-term) antibody |
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Rabbit | Ig | Aff - Purified | Hu | F, WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
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C12049-1 | AIM2 antibody |
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Rabbit | Aff - Purified | Hu | E, WB |
50 µg /
€230.00
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Assay Biotech | |||||||
C12049-2 | AIM2 antibody |
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Rabbit | Aff - Purified | Hu | E, WB |
0.1 mg /
€330.00
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Assay Biotech |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN203120 | AIM2 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN203120BN | AIM2 - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN203120LP | AIM2 - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN203120RB | AIM2 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC203120L2V | Lenti ORF particles, AIM2 (mGFP-tagged)-Human absent in melanoma 2 (AIM2), 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC203120L1V | Lenti ORF particles, AIM2 (Myc-DDK-tagged)-Human absent in melanoma 2 (AIM2), 200 uL, >10^7 TU/mL |
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200 µl /
€969.00
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OriGene Technologies, Inc. | ||
Mouse Lenti ORF Particles
Catalog No. | ||
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MR200724L2V | Lenti ORF particles, Aim2 (GFP-tagged) - Mouse absent in melanoma 2 (Aim2), 200 uL, >10^7 TU/mL |
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200 µl /
€907.00
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OriGene Technologies, Inc. | ||