AIM2 antibody

Principal name

AIM2 antibody

Alternative names for AIM2 antibody

Absent in melanoma 2, Interferon-inducible protein AIM2

SwissProt ID

O14862 (Human), Q91VJ1 (Mouse)

Gene ID

9447 (AIM2), 383619 (Aim2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Eq (Equine)

Available hosts

Mouse, Rabbit, Goat

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP)

Background of AIM2 antibody

AIM2 (Absent in Melanoma-2) is an interferon-inducible cytosolic protein of the IFI20X/IFI16 family, which is essential for an effective inte immune response. It plays a key role in the defence against bacterial and viral D. AIM2 is essential for inflammasome activation in response to Francisella tularensis, vaccinia virus and Listeria monocytogenes (Ferndes-Alnemri T et al, 2009). It recognizes cytosolic dsD and forms a Caspase-1 activating inflammasome with ASC (apoptosis-associated speck-like protein containing a CARD) protein (Jones JW et al, 2010). The C-termil HIN domain binds double stranded D and acts as a cytosolic dsD sensor. The pyrin domain allows for the association with ASC and formation of the inflammasome. Formation of the AIM2 inflammsome leads to the processing and release of mature IL-1Beta and IL-18 and host cell death (Hornung V et al, 2009). AIM2 plays a role in tumorigenic reversion and may control cell proliferation. It may repress NF-kappaB transcriptiol activity.AIM2 antigen is expressed in a wide variety of tumor types, including neuroectodermal tumors, as well as breast, ovarian and colon carcinomas. AIM2 induces the expression of invasion-associated genes such as VIM and MCAM, whereas downregulates ANXA10 and CDH1. AIM2 reduces breast cancer proliferation and mammary tumor growth and shows a high frequency of frameshift mutations in microsatellite unstable (MSI-H) gastric, endometrial and colorectal cancers.Defects in AIM2expression within immune cells contribute to increased susceptibility to lupus. AIM2 could be used as a tumor antigen target for monitoring vaccine trials or to develop antigen specific active immunotherapy for glioma patients. It may serve as a potential therapeutic gene for future development of AIM2-based gene therapy for human breast cancer (Liu G et al, 2004).

General readings

Woerner,S.M., (2007) Genes Chromosomes Cancer 46 (12), 1080-1089

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AIM2 (C-term) antibody

AP22454PU-N AIM2 antibody staining of IFNbeta-treated WI-38 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

AIM2 antibody

Western blot analysis of extracts from HUVEC cells, using AIM2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

Western blot analysis of extracts from K562 cells and A549 cells, using CSRL1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

AIM2 Antibody(Cat. #TA324972) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the AIM2 antibody detected the AIM2 protein (arrow). Mouse IgM 812CT9.2.2.1 Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

TA326327 (0.3µg/ml) staining of Daudi lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

LCK Antibody (Cat. #TA328184) western blot analysis in HL-60,Jurkat,NCI-H292 cell line lysates (35ug/lane).This demonstrates the LCK antibody detected the LCK protein (arrow). Mouse IgM 812CT9.2.2.1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

Western Blot: AIM2 Antibody (10M5G5) [TA337162] - Analysis using AIM2 antibody. Recombinant human AIM2 probed with AIM2 antibody at 2 ug/ml. Mouse IgG2a 10M5G5 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

Western Blot: AIM2 Antibody (10M2B3) [TA337163] - analysis using AIM2 antibody. Recombinant human AIM2 probed with AIM2 antibody at 2 ug/ml. Mouse IgG2a 10M2B3 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

WB Suggested Anti-AIM2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Lung Rabbit IgG Purified Eq, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

AIM2 antibody

AIM2 Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

AIM2 (N-term) antibody

Western blot analysis of AIM2 Antibody (N-term) (Cat. #AP50126PU-N) in MCF-7, HL-60, K562, Hela cell line lysates (35 µg/lane). AIM2 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AIM2 antibody

Immunofluorescence of purified MaxPab antibody to AIM2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

AIM2 antibody

Western Blot analysis of AIM2 expression in transfected 293T cell line (H00009447-T01) by AIM2 MaxPab polyclonal antibody.

Lane 1: AIM2 transfected lysate(39.27 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

AIM2 antibody

AIM2 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

AIM2 antibody

AIM2 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

AIM2 antibody

Western blot analysis of extracts from HuvEc cells, using AIM2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

AIM2 antibody

Western blot analysis of extracts from HuvEc cells, using AIM2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

AIM2 antibody

Human Lung; WB Suggested Anti-AIM2 Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Lung; AIM2 antibody - N-terminal region (ARP50505_P050) in Human Lung cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

AIM2 antibody

Immunohistochemical analysis of AIM2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

AIM2 antibody

Immunohistochemical analysis of AIM2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

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