AIRE / APECED antibody

Principal name

AIRE / APECED antibody

Alternative names for AIRE / APECED antibody

Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein

SwissProt ID

O43918 (Human), Q9Z0E3 (Mouse)

Gene ID

326 (AIRE)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ChIP assay (ChIP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R)

Background of AIRE / APECED antibody

AIRE is a transcriptional regulator that is thought to be important in controlling tissue-specific expression of genes in the thymus. The precise function of the protein is not well defined. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. The longer AIRE1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE3 includes the same exon 1-8-9 sequences as found in AIRE2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. The resulting protein products of these splice variants differ significantly. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

General readings

Niki S, Oshikawa K, Mouri Y, Hirota F, Matsushima A, Yano M, Han H, Bando Y, Izumi K, Matsumoto M, Nakayama KI, Kuroda N, Matsumoto M. , Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. ,J Clin Invest. 2006 May 1;116(5):1292-1301. Epub 2006 Apr 20. , PMID: 16628255

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AIRE / APECED (isoform 1) antibody

TA303113 staining (0.05ug/ml) of HEK293 cell lysates. Untransfected (Lane 3) and transfected with Human AIRE (lane 4). Data kindly provided by Prof. Pärt Peterson, University of Tartu, Estonia. Goat Aff - Purified Can, Hu, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIRE / APECED antibody

Western blot analysis of extracts of various cell lines, using AIRE antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIRE / APECED (Isoform 1+2) (C-term) antibody

TA302805 (0.5µg/ml) staining of Human Lymph lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu ChIP, E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIRE / APECED (isforms 1 + 2) antibody

TA303185 (0.3µg/ml) staining of human spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIRE / APECED antibody

Western blot analysis of extracts from HeLa cells, treated with Hu (2nM, 24hours), using AIRE (Ab-156) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIRE / APECED antibody

Western blot analysis of extracts from 293 cells, using AIRE antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIRE / APECED antibody

Predicted band size: 58 kDa . Positive control: MCF7, U937, HT29, OVCAR3 and SW620 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: MCF7 cell lysate Lane2: U937 cell lysate Lane3: HT29 cell lysate Lane4: OVCAR3 cell lysate Lane5: SW620 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AIRE / APECED (Center) antibody

AIRE Antibody (Center) (Cat. #TA324375) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AIRE antibody detected the AIRE protein (arrow). Rabbit Ig Aff - Purified Hu, Ms ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

AIRE / APECED antibody

Western blot analysis on HeLa cell lysate using AIRE Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AIRE / APECED antibody

Western blot (WB) analysis of AIRE antibody (Cat.-No.: AP06638PU-N) at 1/500 dilution Lane1: Jurkat whole cell lysate Lane2: Mouse lung tissue lysate Lane3: Rat lung tissue lysate Rabbit Aff - Purified Hu, Ms ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

AIRE / APECED (C-term) antibody

Thymus: Formalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Gorilla, Hu E, P, R
50 µg / €470.00
  Acris Antibodies GmbH

AIRE / APECED (Internal) antibody

Thymus: Formalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bear, Bov, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Prim, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AIRE / APECED pSer156 antibody

Western blot analysis of extracts from HeLa cells treated with Hu using AIRE (Phospho-Ser156) Antibody AP55800PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu WB
0.1 ml / €340.00
  Acris Antibodies GmbH

AIRE / APECED pSer156 antibody

Western blot analysis of extracts from HeLa cells treated with Hu using AIRE (Phospho-Ser156) Antibody AP55800PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu WB
50 µl / €270.00
  Acris Antibodies GmbH

AIRE / APECED antibody

AIRE polyclonal antibody ( Cat # PAB6198 ) staining ( 2.5 µg/ml ) of paraffin embedded human thymus.  Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Hu E, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

AIRE / APECED antibody

AIRE polyclonal antibody ( Cat # PAB7040 ) ( 2.5 µg/ml ) staining of paraffin embedded human thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Hu E, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

AIRE / APECED antibody

AIRE polyclonal antibody ( Cat # PAB7187 ) staining ( 0.05 µg/ml ) of HEK293 cell lysates. Transfected with human AIRE ( lane 1 ) and untransfected ( Lane2 ) . Data kindly provided by Prof. Part Peterson, University of Tartu, Estonia. Goat Hu, Ms E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

AIRE / APECED pSer156 antibody

Western blot analysis of extracts from HeLa cells treated with Hu 2nM 24h, using AIRE (Phospho-Ser156) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

AIRE / APECED pSer156 antibody

Western blot analysis of extracts from HeLa cells treated with Hu 2nM 24h, using AIRE (Phospho-Ser156) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

AIRE / APECED antibody

Western blot analysis of extracts from HeLa cells, treated with Hu 2nM 24h, using AIRE (Ab-156) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

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