AKR1C2 / DDH2 antibody

Principal name

AKR1C2 / DDH2 antibody

Alternative names for AKR1C2 / DDH2 antibody

3-alpha-HSD3, Dihydrodiol dehydrogenase 2, Aldo-keto reductase family 1 member C2, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, Dihydrodiol dehydrogenase/bile acid-binding protein, Chlordecone reductase homolog HAKRD

SwissProt ID

P52895 (Human)

Gene ID

1646 (AKR1C2)

Available reactivities

Hu (Human), Mam (Mammalia), Ms (Mouse), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Rt (Rat), Sh (Sheep)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of AKR1C2 / DDH2 antibody

DDH is a member of aldo-keto reductase superfamily (1,2), which catalyzes reduction of aldehyde or ketone to a corresponding alcohol by using NADH or NADPH as a cofactor. In liver, the enzyme is abundantly located in the cytoplasm as a monomeric 34-36 kDa protein (3,4). Interestingly, by differential display Shen et al. (5) has shown that overexpression of DDH could be identified in ethacrynic acid-induced drug-resistant human colon cancer cells. Detection of DDH overexpression in drug-resistant human stomach cancer cells, which were selected by the gradual adaptation to daunorubicin, further suggested that DDH might be associated with the drug-resistance in cancer cells (6). In a recent study, DDH expression was further shown to have prognostic significance in patients with NSCLC. By using an immunohistochemical method to determine DDH expression in surgical specimens, DDH expression was identified in patients with leukemia, lung cancer, esophageal cancer, transitional cancer and breast cancer. Furthermore, overexpression of DDH was confirmed by immunoblotting and in situ hybridization. Correlation between clinicopathological parameters and DDH expression as well as the prognostic significance of DDH expression in patients with advanced cancer was indicated.

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AKR1C2 / DDH2 antibody

  Rabbit polyclonal anti-AKR1C2 antibody  
Western blot analysis of extracts from COLO cells, using AKR1C2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AKR1C2 / DDH2 antibody

  Rabbit Polyclonal Anti-AKR1C2 Antibody  
WB Suggested Anti-AKR1C2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

AKR1C2 / DDH2 antibody

  Rabbit Polyclonal Anti-AKR1C2 Antibody  
WB Suggested Anti-AKR1C2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

AKR1C2 / DDH2 antibody

Figure 1. Immunoperoxidase staining of formalin-fixed paraffin embedded human lung cancer tissue showing cytoplasmic localization of dihydrodiol dehydrogenase. Mouse IgG1 T101 Hu, Mam, Ms, Por E, ICC/IF, P, WB
0.1 ml / €500.00
  Acris Antibodies GmbH

AKR1C2 / DDH2 (C-term) antibody

AKR1C2 Antibody (C-term) (Cat. #AP50131PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AKR1C2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AKR1C2 / DDH2 antibody

Western blot analysis of extracts from COLO cells, using AKR1C2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

AKR1C2 / DDH2 antibody

Western blot analysis of extracts from COLO cells, using AKR1C2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

AKR1C2 - human gene knockout kit via CRISPR

AKR1C2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AKR1C2 - human gene knockout kit via CRISPR

AKR1C2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AKR1C2 - human gene knockout kit via CRISPR

AKR1C2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AKR1C2 - human gene knockout kit via CRISPR

AKR1C2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AKR1C2 / DDH2

  Recombinant protein of human aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) (AKR1C2), tran  
AKR1C2 / DDH2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

AKR1C2 / DDH2

  Recombinant protein of human aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) (AKR1C2), tran  
AKR1C2 / DDH2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

AKR1C2 / DDH2

  Recombinant protein of human similar to hCG2017792 (LOC100134257)  
AKR1C2 / DDH2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €399.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

AKR1C2 overexpression lysate

AKR1C2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

AKR1C2 overexpression lysate

AKR1C2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

AKR1C2 overexpression lysate

AKR1C2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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