AKR1C3 / DDH3 antibody

Principal name

AKR1C3 / DDH3 antibody

Alternative names for AKR1C3 / DDH3 antibody

HSD17B5, KIAA0119, PGFS, Dihydrodiol dehydrogenase 3, 3-alpha-HSD type II, 17-beta-hydroxysteroid dehydrogenase type 5, Aldo-keto reductase family 1 member C3, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-HSD type II, brain, Testosterone 17-beta-dehydrogenase 5, Prostaglandin F synthase, Dihydrodiol dehydrogenase type I, Chlordecone reductase homolog HAKRb, HA1753

SwissProt ID

P42330 (Human)

Gene ID

8644 (AKR1C3)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of AKR1C3 / DDH3 antibody

DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20Alpha- or 3Alpha-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1 while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3Alpha-HSD are alternate designations for DD3, while DD4 also can be called AKR1C4, CD or CHDR. DD1 and DD2 are 20Alpha-HSDs, whereas DD3 and DD4 are the 3Alpha-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20Alpha-HSD catalyzes the reaction of progesterone to the inactive form 20Alpha-hydroxyprogesterone. The 3Alpha-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver.

General readings

Iczkowski KA, Qiu J, Qian J, Somerville MC, Rittmaster RS, Andriole GL, Bostwick DG.
The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate.
Urology. 2005 Jan;65(1):76-82.
PMID: 15667867

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AKR1C3 / DDH3 antibody

Western blot analysis of extracts of Jurkat cell line, using AKR1C3 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 antibody

TA302991 (0.03µg/ml) staining of human breast lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 antibody

Western blot analysis of MCF-7 and fetal liver lysates with anti-AKR1C3 antibody (1:500). This antibody identified a band of ~37kDa in MCF-7 and fetal liver lysates. Rabbit Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 (Center) antibody

AKR1C3 Antibody (Center) (Cat. #TA324422) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the AKR1C3 antibody detected the AKR1C3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 (C-term) antibody

Small intestine: Fromalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AKR1C3 / DDH3 (N-term) antibody

AKR1C3 Antibody (N-term) (Cat. #AP50133PU-N) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the AKR1C3 antibody detected the AKR1C3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AKR1C3 / DDH3 antibody

AKR1C3 MaxPab polyclonal antibody. Western Blot analysis of AKR1C3 expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

AKR1C3 / DDH3 antibody

AKR1C3 MaxPab polyclonal antibody. Western Blot analysis of AKR1C3 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

AKR1C3 / DDH3 antibody

AKR1C3 MaxPab polyclonal antibody. Western Blot analysis of AKR1C3 expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

AKR1C3 / DDH3 antibody

AKR1C3 MaxPab rabbit polyclonal antibody. Western Blot analysis of AKR1C3 expression in human colon. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

AKR1C3 / DDH3 antibody

AKR1C3 polyclonal antibody ( Cat # PAB6737 ) ( 0.03 µg/ml ) staining of human breast lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

AKR1C3 / DDH3 antibody

Western blot analysis of extracts from HeLa/COLO cells, using AKR1C3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

AKR1C3 / DDH3 antibody

Western blot analysis of extracts from HeLa/COLO cells, using AKR1C3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

AKR1C3 / DDH3 antibody

Western Blot: AKR1C3 Antibody [NB100-1940] - NB100-1940 (0.03ug/ml) staining of Human Breast lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Ig Fraction Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

AKR1C3 / DDH3 antibody

Immunofluorescence: AKR1C3 Antibody [NBP1-31378] - Immunofluorescence analysis of HeLa, using NBP1-31378 at 1:200 dilution. Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

AKR1C3 / DDH3 antibody

Western  Blot:  AKR1C3 Antibody [NBP1-33556] – Western blot analysis of AKR1C3 on Hela cells (Lane A), Hep G2 lysates (Lane B) and Molt-4 lysates (Lane C) using NBP1-33556 at a dilution of 1:1000. Rabbit IgG Hu P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AKR1C3 / DDH3

AKR1C3 / DDH3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 (1-323, His-tag)

Recombinant human AKR1C3 (1-323 aa), His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

AKR1C3 / DDH3 (1-323, His-tag)

Recombinant human AKR1C3 (1-323 aa), His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

AKR1C3 / DDH3

AKR1C3 / DDH3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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