AKR1C3 / DDH3 antibody

Principal name

AKR1C3 / DDH3 antibody

Alternative names for AKR1C3 / DDH3 antibody

HSD17B5, KIAA0119, PGFS, Dihydrodiol dehydrogenase 3, 3-alpha-HSD type II, 17-beta-hydroxysteroid dehydrogenase type 5, Aldo-keto reductase family 1 member C3, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-HSD type II, brain, Testosterone 17-beta-dehydrogenase 5, Prostaglandin F synthase, Dihydrodiol dehydrogenase type I, Chlordecone reductase homolog HAKRb, HA1753

SwissProt ID

P42330 (Human)

Gene ID

8644 (AKR1C3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of AKR1C3 / DDH3 antibody

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20 alpha hydroxy progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation.

General readings

Iczkowski KA, Qiu J, Qian J, Somerville MC, Rittmaster RS, Andriole GL, Bostwick DG. The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. Urology. 2005 Jan;65(1):76-82.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AKR1C3 / DDH3 antibody

  AKR1C3 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of Jurkat cell line, using AKR1C3 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 antibody

  Goat Polyclonal Antibody against AKR1C3  
TA302991 (0.03µg/ml) staining of human breast lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 antibody

  Rabbit anti-AKR1C3 polyclonal antibody  
Western blot analysis of MCF-7 and fetal liver lysates with anti-AKR1C3 antibody (1:500). This antibody identified a band of ~37kDa in MCF-7 and fetal liver lysates. Rabbit Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 (Center) antibody

  Rabbit polyclonal AKR1C3 Antibody (Center)  
AKR1C3 Antibody (Center) (Cat. #TA324422) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the AKR1C3 antibody detected the AKR1C3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 (C-term) antibody

Small intestine: Fromalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AKR1C3 / DDH3 (N-term) antibody

AKR1C3 Antibody (N-term) (Cat. #AP50133PU-N) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the AKR1C3 antibody detected the AKR1C3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AKR1C3 / DDH3 antibody

Western blot analysis of extracts from HeLa/COLO cells, using AKR1C3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

AKR1C3 / DDH3 antibody

Western blot analysis of extracts from HeLa/COLO cells, using AKR1C3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

AKR1C3 - human gene knockout kit via CRISPR

AKR1C3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AKR1C3 - human gene knockout kit via CRISPR

AKR1C3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AKR1C3 - human gene knockout kit via CRISPR

AKR1C3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AKR1C3 / DDH3

  Recombinant protein of human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3)  
AKR1C3 / DDH3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

AKR1C3 / DDH3 (1-323, His-tag)

Recombinant human AKR1C3 (1-323 aa), His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

AKR1C3 / DDH3 (1-323, His-tag)

Recombinant human AKR1C3 (1-323 aa), His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

AKR1C3 overexpression lysate

AKR1C3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AKR1C3 (mGFP-tagged) - Human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3), 200 uL, >10^7 TU/mL

Lenti ORF particles, AKR1C3 (mGFP-tagged) - Human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, AKR1C3 (Myc-DDK tagged) - Human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3) , 200 uL, >10^7 TU/mL

Lenti ORF particles, AKR1C3 (Myc-DDK tagged) - Human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

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