AKTIP / FTS antibody

Principal name

AKTIP / FTS antibody

Alternative names for AKTIP / FTS antibody

FT1, Fused toes protein homolog, AKT-interacting protein

SwissProt ID

Q64362 (Mouse), Q9H8T0 (Human)

Gene ID

64400 (AKTIP), 14339 (Aktip)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of AKTIP / FTS antibody

AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

General readings

"Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt." Remy I., Michnick S.W. Mol. Cell. Biol. 24:1493-1504(2004)
"An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex." Xu L., Sowa M.E., Chen J., Li X., Gygi S.P., Harper J.W. Mol. Biol. Cell 19:5059-5071(2008)

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AKTIP / FTS antibody

  Rabbit Polyclonal Anti-AKTIP Antibody  
WB Suggested Anti-AKTIP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Muscle Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

AKTIP - human gene knockout kit via CRISPR

AKTIP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AKTIP - human gene knockout kit via CRISPR

AKTIP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AKTIP - human gene knockout kit via CRISPR

AKTIP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AKTIP - human gene knockout kit via CRISPR

AKTIP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aktip - mouse gene knockout kit via CRISPR

Aktip - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Aktip - mouse gene knockout kit via CRISPR

Aktip - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aktip - mouse gene knockout kit via CRISPR

Aktip - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aktip - mouse gene knockout kit via CRISPR

Aktip - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AKTIP / FTS (transcript variant 2)

  Recombinant protein of human AKT interacting protein (AKTIP), transcript variant 2  
AKTIP / FTS Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AKTIP (mGFP-tagged) - Human AKT interacting protein (AKTIP), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, AKTIP (mGFP-tagged) - Human AKT interacting protein (AKTIP), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, AKTIP (Myc-DDK tagged) - Human AKT interacting protein (AKTIP), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, AKTIP (Myc-DDK tagged) - Human AKT interacting protein (AKTIP), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Aktip (GFP-tagged) - Mouse thymoma viral proto-oncogene 1 interacting protein (Aktip), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aktip (GFP-tagged) - Mouse thymoma viral proto-oncogene 1 interacting protein (Aktip), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aktip (Myc-DDK-tagged) - Mouse thymoma viral proto-oncogene 1 interacting protein (Aktip), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aktip (Myc-DDK-tagged) - Mouse thymoma viral proto-oncogene 1 interacting protein (Aktip), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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