AKTIP / FTS antibody

Principal name

AKTIP / FTS antibody

Alternative names for AKTIP / FTS antibody

FT1, Fused toes protein homolog, AKT-interacting protein

SwissProt ID

Q64362 (Mouse), Q9H8T0 (Human)

Gene ID

64400 (AKTIP)

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of AKTIP / FTS antibody

AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

General readings

"Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt." Remy I., Michnick S.W. Mol. Cell. Biol. 24:1493-1504(2004)
"An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex." Xu L., Sowa M.E., Chen J., Li X., Gygi S.P., Harper J.W. Mol. Biol. Cell 19:5059-5071(2008)

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AKTIP / FTS antibody

WB Suggested Anti-AKTIP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Muscle Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

AKTIP / FTS antibody

AKTIP / FTS Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

AKTIP / FTS antibody

Western Blot analysis of AKTIP expression in transfected 293T cell line (H00064400-T01) by AKTIP MaxPab polyclonal antibody.

Lane 1: FTS transfected lysate(32.12 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

AKTIP / FTS antibody

Western Blot analysis of AKTIP expression in transfected 293T cell line (H00064400-T01) by AKTIP MaxPab polyclonal antibody.

Lane 1: FTS transfected lysate(32.12 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

AKTIP / FTS antibody

AKTIP / FTS Mouse IgG2a 2B2 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

AKTIP / FTS antibody

Western Blot analysis of FTS expression in transfected 293T cell line by FTS monoclonal antibody (M02), clone 2A11.

Lane 1: FTS transfected lysate(33.1 KDa).
Lane 2: Non-transfected lysate. Mouse IgG1 2A11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

AKTIP / FTS antibody

AKTIP / FTS Mouse IgG1 6G8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

AKTIP / FTS antibody

Human Muscle; WB Suggested Anti-AKTIP Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Muscle; AKTIP antibody - middle region (ARP56199_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

AKTIP / FTS antibody

Western Blot: FTS Antibody [NBP1-53106] - This Anti-AKTIP antibody was used in Western Blot of Fetal Muscle tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AKTIP / FTS (transcript variant 2)

AKTIP / FTS Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

AKTIP / FTS

AKTIP / FTS Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

AKTIP / FTS

AKTIP / FTS Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

FTS 293T Cell Transient Overexpression Lysate(Denatured)

FTS 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

13 Item(s)

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