ALAS1 antibody

Principal name

ALAS1 antibody

Alternative names for ALAS1 antibody

ALAS3, ALASH, Delta-ALA synthetase, 5-aminolevulinate synthase nonspecific mitochondrial, 5-aminolevulinic acid synthase, Delta-aminolevulinate synthase

SwissProt ID

A6QLI6 (Bovin), P13195 (Rat), P13196 (Human)

Gene ID

211 (ALAS1), 65155 (Alas1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of ALAS1 antibody

Official Gene Symbol: ALAS1 Gene ID: 211(human) Gene Map Locus: 3p21.1(human) ALAS-1 (EC 2.3.1.37) is a nuclear-encoded mitochondrial matrix enzyme catalyzing the condensation of glycine with succinyl-CoA to form delta-amino levulite, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.

General readings

Jung,M., (2007) Urologe A 46 (9), 1083-1084

18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ALAS1 antibody

  Anti-ALAS1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast and thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using ALAS1 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ALAS1 antibody

  Anti-ALAS1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using ALAS1 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ALAS1 antibody

  Rabbit Polyclonal Anti-ALAS1 Antibody  
WB Suggested Anti-ALAS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ALAS1 antibody

  Rabbit Polyclonal Alas1 Antibody  
Western Blot: Alas1 Antibody [TA336353] - analysis of HepG2 cell lysate using ALAS1 antibody at1 ug/ml. Rabbit Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ALAS1 antibody

  ALAS1 mouse monoclonal antibody, clone OTI1C5 (formerly 1C5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALAS1 (RC219938, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ALAS1.(1:2000) Mouse IgG1 OTI1C5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALAS1 antibody

  ALAS1 mouse monoclonal antibody, clone OTI5D5 (formerly 5D5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALAS1 (RC219938, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ALAS1.(1:2000) Mouse IgG1 OTI5D5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALAS1 (480-530) antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ALAS1 - human gene knockout kit via CRISPR

ALAS1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ALAS1 - human gene knockout kit via CRISPR

ALAS1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ALAS1 - human gene knockout kit via CRISPR

ALAS1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ALAS1 - human gene knockout kit via CRISPR

ALAS1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ALAS1 (full length, N-term HIS tag, transcript variant 2)

  Purified recombinant protein of Homo sapiens aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
ALAS1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ALAS1 (mGFP-tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ALAS1 (mGFP-tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, ALAS1 (mGFP-tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ALAS1 (mGFP-tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, ALAS1 (Myc-DDK tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ALAS1 (Myc-DDK tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, ALAS1 (Myc-DDK tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ALAS1 (Myc-DDK tagged) - Human aminolevulinate, delta-, synthase 1 (ALAS1), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Alas1 (GFP-tagged ORF) - Rat aminolevulinate, delta-, synthase 1 (Alas1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Alas1 (GFP-tagged ORF) - Rat aminolevulinate, delta-, synthase 1 (Alas1), 200 uL, >10^7 TU/mL  
200 µl / €1,310.00
  OriGene Technologies, Inc.

Lenti ORF particles, Alas1 (Myc-DDK-tagged ORF) - Rat aminolevulinate, delta-, synthase 1 (Alas1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Alas1 (Myc-DDK-tagged ORF) - Rat aminolevulinate, delta-, synthase 1 (Alas1), 200 uL, >10^7 TU/mL  
200 µl / €1,172.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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