ALDH1L1 / FTHFD antibody

Principal name

ALDH1L1 / FTHFD antibody

Alternative names for ALDH1L1 / FTHFD antibody

10-formyltetrahydrofolate dehydrogenase, Aldehyde dehydrogenase family 1 member L1

SwissProt ID

O75891 (Human), P28037 (Rat), Q8R0Y6 (Mouse)

Gene ID

10840 (ALDH1L1), 107747 (Aldh1l1), 64392

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Ze (Zebrafish), African clawed frog, Prim (Primate), Can (Canine), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Luminex (LMNX)

Background of ALDH1L1 / FTHFD antibody

ALDH1L1 (aldehyde dehydrogese family 1, member 1) is a part of the Aldehyde dehydrogeses (ALDH) superfamily, which is a group of enzymes that catalyze oxidation (dehydrogetion) of aldehydes. To date, nineteen ALDH genes have been identified within the human genome. They belong to 15 families in ALDH superfamily. ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, nicotimide adenine dinucleotide phosphate (DP+), and water to tetrahydrofolate, DPH, and carbon dioxide. ALDH1L1 expression is tissue-specific and is highly expressed in the liver, representing up to 1% of the total pool of soluble cell proteins in the mammalian liver. In an earlier study, Cahoy et al (J Neurosci.28:264-78 (2008)) applied FACS (Fluorescent-Activated Cell Sorting) to isolate astrocytes from EGFP (Enhanced Green Fluorescent Protein) transgenic-mouse, then created a transcriptome database of the expression levels of 20,000 genes by gene profiling of neurons, astrocytes and oligodedrocytes using Affymetrix GeneChip Arrays. They identified ALDH1L1 as a highly and specifically expressed gene in astrocytes. ALDH1L1 is more widely expressed throughout the brain, while astrocyte marker GFAP shows more predomint expression in white matter. In addition, loss of function or expression of ALDH1L1 is associated with decreased apoptosis, increased cell motility, and cancer progression, suggesting its role as a biomarker and a target in cancer therapy.

General readings

Lee,K.M., (2007) Hum. Genet. 122 (5), 525-533

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-ALDH1L1 mouse monoclonal antibody. (UM500039; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2b UMAB43 Purified Can, Hu, Mky, Ms, Rt P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-ALDH1L1 mouse monoclonal antibody. (UM500040; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB44 Purified Can, Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-ALDH1L1 mouse monoclonal antibody. (UM500041; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB45 Purified Can, Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-ALDH1L1 mouse monoclonal antibody. (UM500039; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2b UMAB43 Purified Can, Hu, Mky, Ms, Rt P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-ALDH1L1 mouse monoclonal antibody. (UM500040; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB44 Purified Can, Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-ALDH1L1 mouse monoclonal antibody. (UM500041; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB45 Purified Can, Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ALDH1L1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501850) Mouse IgG1 OTI3D2 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-ALDH1L1 mouse monoclonal antibody. (TA501851) Mouse IgG1 OTI4C11 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-ALDH1L1 mouse monoclonal antibody. (TA501852) Mouse IgG1 OTI3B11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-ALDH1L1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501853) Mouse IgG2b OTI1H6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ALDH1L1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501854) Mouse IgG1 OTI4D5 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Immunofluorescent staining of HeLa cells using anti-ALDH1L1 mouse monoclonal antibody (TA501855). Mouse IgG1 OTI7B7 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Anti-ALDH1L1 mouse monoclonal antibody (TA501867) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ALDH1L1(RC213720). Mouse IgG2a OTI7G6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ALDH1L1 (RC213720, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ALDH1L1. Mouse IgG1 OTI2A6 Purified Can, Hu, Mky, Rt F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-ALDH1L1 mouse monoclonal antibody. (TA501870) Mouse IgG2a OTI5G8 Purified Can, Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-ALDH1L1 mouse monoclonal antibody. (TA501871) Mouse IgG1 OTI6A10 Purified Can, Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ALDH1L1 / FTHFD antibody

ALDH1L1 ELISA with 5G8 Capture (TA600397) and 7G6 Detection (TA700397) Antibodies. Substrate used: Recombinant Human ALDH1L1 (TP313720) Mouse IgG1 OTI5G8 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

ALDH1L1 / FTHFD antibody

ALDH1L1 ELISA with 7G6 Capture (TA600398) and 5G8 Detection (TA700395) Antibodies. Substrate used: Recombinant Human ALDH1L1 (TP313720) Mouse IgG1 OTI5G8 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

ALDH1L1 / FTHFD antibody

ALDH1L1 ELISA with 5G8 Capture (TA600397) and 1H6 Detection (TA700396) Antibodies. Substrate used: Recombinant Human ALDH1L1 (TP313720) Mouse IgG1 OTI1H6 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

ALDH1L1 / FTHFD antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG3 3E9 Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

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