ALKBH2 / ABH2 antibody

Principal name

ALKBH2 / ABH2 antibody

Alternative names for ALKBH2 / ABH2 antibody

Oxy DC1, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, Alkylated DNA repair protein alkB homolog 2

SwissProt ID

Q58DM4 (Bovin), Q6NS38 (Human), Q6P6J4 (Mouse)

Gene ID

121642 (ALKBH2), 231642 (Alkbh2)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of ALKBH2 / ABH2 antibody

The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.

General readings

Rinqvoll J., et al. (2008) Cancer Res. 68:4142-4149.
Lee D H., et al. (2005) J Biol Chem. 280:39448-39459.

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ALKBH2 / ABH2 (C-term) antibody

  Rabbit Polyclonal ALKBH2 Antibody  
Western blot analysis of ALKBH2 in human kidney tissue lysate with ALKBH2 antibody at (A) 1 and (B) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

ALKBH2 / ABH2 antibody

  Anti-ALKBH2 Rabbit Polyclonal Antibody  
Predicted band size: 29 kDa . Positive control: Human fetal liver and seminoma tissue, RAW264.7 cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lane1: Human fetal liver tissue lysate Lane2: Human seminoma tissue lysate Lane3: RAW264.7 cell lysate Lysates: 40 ug per lane Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

ALKBH2 / ABH2 antibody

  Anti-ALKBH2 Rabbit Polyclonal Antibody  
Predicted band size: 29 kDa . Positive control: Human fetal liver and seminoma tissue, RAW264.7 cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lane1: Human fetal liver tissue lysate Lane2: Human seminoma tissue lysate Lane3: RAW264.7 cell lysate Lysates: 40 ug per lane Primary antibody: 1/650 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

ALKBH2 / ABH2 antibody

  Rabbit Polyclonal Anti-ALKBH2 Antibody  
WB Suggested Anti-ALKBH2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

ALKBH2 / ABH2 (C-term) antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €380.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ALKBH2 / ABH2 (transcript variant 2)

  Recombinant protein of human alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 2  
ALKBH2 / ABH2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ALKBH2 / ABH2 (transcript variant 1)

  Recombinant protein of human alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 1  
ALKBH2 / ABH2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ALKBH2 / ABH2 (transcript variant 3)

  Recombinant protein of human alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 3  
ALKBH2 / ABH2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ALKBH2 / ABH2 (1-261, His-tag)

ALKBH2 / ABH2 Human Purified > 90 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

ALKBH2 / ABH2 (1-261, His-tag)

ALKBH2 / ABH2 Human Purified > 90 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

ALKBH2 overexpression lysate

ALKBH2 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

ALKBH2 overexpression lysate

ALKBH2 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

ALKBH2 overexpression lysate

ALKBH2 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ALKBH2 (mGFP-tagged) - Human alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, ALKBH2 (mGFP-tagged) - Human alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, ALKBH2 (Myc-DDK tagged) - Human alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ALKBH2 (Myc-DDK tagged) - Human alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Alkbh2 (GFP-tagged) - Mouse alkB, alkylation repair homolog 2 (E. coli) (Alkbh2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Alkbh2 (GFP-tagged) - Mouse alkB, alkylation repair homolog 2 (E. coli) (Alkbh2), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Alkbh2 (Myc-DDK-tagged) - Mouse alkB, alkylation repair homolog 2 (E. coli) (Alkbh2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Alkbh2 (Myc-DDK-tagged) - Mouse alkB, alkylation repair homolog 2 (E. coli) (Alkbh2), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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