Allergen Fel D1 chain 1 antibody

Principal name

Allergen Fel D1 chain 1 antibody

Alternative names for Allergen Fel D1 chain 1 antibody

Allergen Fel d I-A, Allergen Cat-1, AG4, CH1, Major allergen I polypeptide chain 1

SwissProt ID

P30438 (Felca)

Gene ID

677877 (LOC677877)

Available reactivities

Fe (Feline), Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts


Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of Allergen Fel D1 chain 1 antibody

A number of house pet bourn allergens have been studied for allergic reactions in general population. Some of these allergens namely Fel D1 (cat), Can f1(dog), Der p1 and Der f1 (mite) are carried by the pet owners to the public places like classroom, restaurants, public library etc., and the clothes and upholstered furniture act as reservoirs for these allergens. Domestic cat (Felis domestica) is an important source of indoor allergen Fel D1, that affected a large population. Fel D1 is also established to cause cat induce asthma in sensitive patients. The levels of Fel d1 and Can f1 were high in homes of former pet-owners compared to the homes without pets.
Children with mild allergy to animal dander, may have profound increase in bronchial sensitivity (increased sputum esinophil peroxidase (EPO) and myeloperoxidase (MPO) activity as a result of constant exposure of animal allergens (Fel D1 and Can f1) at public places. Allergic reactions to Fel D1 is effectively reduced by conventional immunotherapy in many patients, but this type of immunotherapy has severe reactions, including anaphylaxix and requires several years of injections for successful desensitization. Several strategies have been employed to address these issues including use of cat allergen peptides (2), chimerric constructs of Fel D1 and Fc portion of human IgEs (4). The synthetic cat allergen peptides lack the tertiary structure of native Fel D1 and posses reduced capacity to bind Fel D1-specific IgE. These peptides when given to patients sensitive to cat allergens showed improvement in pulmonary function and tolerance to cats (2). The exposure of chimeric human –cat fusion protein composed of truncated human IgGFcgamma1 and the Fel D1. the chimeric protein induce dose dependent inhibition of Fel D1-driven IgE mediated histamine release form cat allergic donors (3).
The allergen is a 38 kDa dimer composed of two 19 kDa subunits. Each 19 kDa subunit comprises two disulfide linked polypeptide chains, a light alpha-chain and a heavy beta-chain containing an N-linked oligosaccharide. The alfa light chain and the heavy beta chain are linked in an anti-parallel configuration. The Fel D1glycosylation atr Asn 33 is of heterogeneous triantennary structure caused by terminal sialic acid and fucose residues attached to beta-galactose residues.

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