ALOX5AP / FLAP antibody

Principal name

ALOX5AP / FLAP antibody

Alternative names for ALOX5AP / FLAP antibody

MK-886-binding protein, Arachidonate 5-lipoxygenase-activating protein

SwissProt ID

P20291 (Rat), P20292 (Human), P30355 (Mouse), P30356 (Pig), Q148F2 (Bovin)

Gene ID

241 (ALOX5AP)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse)

Available hosts

Goat, Rabbit

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Dot blot (Dot)

Background of ALOX5AP / FLAP antibody

Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

General readings

Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson G, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Johannsson H, Gudmundsdottir O, Gurney ME, Sainz J, Thorhallsdottir M, Andresdottir M, Frigge ML, Topol EJ, Kong A, Gudnason V, Hakonarson H, Gulcher JR, Stefansson K.
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet. 2004 Mar;36(3):233-9. Epub 2004 Feb 08. PMID: 14770184

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ALOX5AP / FLAP (98-161) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

ALOX5AP / FLAP (28-40) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Can, Elephant, Eq, Hst, Hu, Mky, Op, Platypus, Por, Prim, Rb, Sh E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

TA302488 (0.1µg/ml) staining of Human U937 cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ALOX5AP / FLAP (C-term) antibody

ALOX5AP / FLAP Goat Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ALOX5AP / FLAP Control Peptide

ALOX5AP / FLAP Purified
50 µg / €210.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

Western blot using Antigen Immunoaffinity purified FLAP antibody (cat.-No. AP05297PU-N at 5 µg/ml) on Human kidney cell lysate (15 µg/Lane). Secondary antibody: Mouse anti-Rabbit HRP at 1/75k dilution. 
Visualized using Pierce West Femto substrate system. Exposure for 5 minutes Rabbit Aff - Purified Hu WB
10 Blots / €480.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

Western blot using FLAP antibody (cat.-No. AP05297SU-N at 5 µg/ml) on Human kidney cell lysate (15 µg/Lane). Secondary antibody: Mouse anti-Rabbit HRP at 1/25k dilution. Visualized using Pierce West Femto substrate system. Exposure for 5 minutes Rabbit Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ALOX5AP antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ALOX5AP / FLAP (148-161) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bov, Bt, Can, Elephant, Eq, Hu, L, Mky, Ms, Op, Platypus, Prim, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

ALOX5AP / FLAP Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

ALOX5AP / FLAP antibody

ALOX5AP polyclonal antibody ( Cat # PAB7117 ) ( 0.1 µg/ml ) staining of human U-937 cell lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

ALOX5AP / FLAP antibody

Western blot using ALOX5AP polyclonal antibody on human kidney cell lysate.
Lysate used at 15 µg/lane, antibody used at 5 µg/ml. Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

ALOX5AP / FLAP antibody

Immunohistochemistry-Paraffin: FLAP Antibody [NB100-53797] - (3.8ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

ALOX5AP / FLAP antibody

ALOX5AP / FLAP Goat IgG Aff - Purified Hu E
0.1 mg / €400.00
  Novus Biologicals Inc.

ALOX5AP / FLAP antibody

Western Blot: FLAP Antibody [NBP1-30984] - Western blot analysis of FLAP on Raji, diluted at 1:1000 with 12% SDS PAGE gel. Rabbit IgG Hu Dot, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

ALOX5AP / FLAP antibody

Immunohistochemistry-Paraffin: FLAP Antibody [NBP1-84666] - Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside the reaction centra. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

ALOX5AP / FLAP antibody

Western Blot: FLAP Antibody (EPR5640) [NBP1-95197] (A) Raji, (B) THP-1, (C) HepG2, and (D) K562 cell lysates using anti-FLAP. Rabbit EPR5640 Purified Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ALOX5AP / FLAP

ALOX5AP / FLAP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

ALOX5AP / FLAP

ALOX5AP / FLAP Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ALOX5AP overexpression lysate

ALOX5AP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

20 Item(s)

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