ALOX5AP / FLAP antibody

Principal name

ALOX5AP / FLAP antibody

Alternative names for ALOX5AP / FLAP antibody

MK-886-binding protein, Arachidonate 5-lipoxygenase-activating protein

SwissProt ID

P20291 (Rat), P20292 (Human), P30355 (Mouse), P30356 (Pig), Q148F2 (Bovin)

Gene ID

241 (ALOX5AP), 11690 (Alox5ap), 29624

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Sh (Sheep), Bear, Bt (Bat), Ms (Mouse), Rt (Rat), L (Lizard)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of ALOX5AP / FLAP antibody

Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ALOX5AP / FLAP (28-40) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Elephant, Hu, Mky, Platypus E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

  Goat Polyclonal Antibody against FLAP / ALOX5AP (internal)  
TA302488 (0.1µg/ml) staining of Human U937 cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ALOX5AP / FLAP (C-term) antibody

  Goat Anti-FLAP / ALOX5AP (C Term) Antibody  
ALOX5AP / FLAP Goat Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ALOX5AP / FLAP Control Peptide

ALOX5AP / FLAP Purified
50 µg / €220.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

Western blot using Antigen Immunoaffinity purified FLAP antibody (cat.-No. AP05297PU-N at 5 µg/ml) on Human kidney cell lysate (15 µg/Lane). Secondary antibody: Mouse anti-Rabbit HRP at 1/75k dilution. 
Visualized using Pierce West Femto substrate system. Exposure for 5 minutes Rabbit Aff - Purified Hu WB
0.1 mg / €490.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

Western blot using FLAP antibody (cat.-No. AP05297SU-N at 5 µg/ml) on Human kidney cell lysate (15 µg/Lane). Secondary antibody: Mouse anti-Rabbit HRP at 1/25k dilution. Visualized using Pierce West Femto substrate system. Exposure for 5 minutes Rabbit Purified Hu WB
0.1 mg / €380.00
  Acris Antibodies GmbH

ALOX5AP / FLAP antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ALOX5AP antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ALOX5AP / FLAP (148-161) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Elephant, Hu, Platypus E, P
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ALOX5AP - human gene knockout kit via CRISPR

ALOX5AP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ALOX5AP - human gene knockout kit via CRISPR

ALOX5AP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ALOX5AP - human gene knockout kit via CRISPR

ALOX5AP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ALOX5AP - human gene knockout kit via CRISPR

ALOX5AP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Alox5ap - mouse gene knockout kit via CRISPR

Alox5ap - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Alox5ap - mouse gene knockout kit via CRISPR

Alox5ap - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Alox5ap - mouse gene knockout kit via CRISPR

Alox5ap - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Alox5ap - mouse gene knockout kit via CRISPR

Alox5ap - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ALOX5AP / FLAP

  Recombinant protein of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP)  
ALOX5AP / FLAP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

ALOX5AP overexpression lysate

ALOX5AP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ALOX5AP (mGFP-tagged) - Human arachidonate 5-lipoxygenase-activating protein (ALOX5AP), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ALOX5AP (mGFP-tagged) - Human arachidonate 5-lipoxygenase-activating protein (ALOX5AP), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, ALOX5AP (Myc-DDK tagged) - Human arachidonate 5-lipoxygenase-activating protein (ALOX5AP), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ALOX5AP (Myc-DDK tagged) - Human arachidonate 5-lipoxygenase-activating protein (ALOX5AP), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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