Alpha-2-HS-glycoprotein / AHSG antibody

Principal name

Alpha-2-HS-glycoprotein / AHSG antibody

Alternative names for Alpha-2-HS-glycoprotein / AHSG antibody

Fetuin A, AHSG, FETUA, PRO2743, Ba-alpha-2-glycoprotein, Alpha-2-Z-globulin

SwissProt ID

P02765 (Human), P12763 (Bovin), P24090 (Rat), P29699 (Mouse), P29700 (Pig)

Gene ID

197 (AHSG), 280988, 11625 (Ahsg)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Sheep, Goat, Rat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunodiffusion (ID), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Alpha-2-HS-glycoprotein / AHSG antibody

Human Fetuin (2-Heremans-Schmid-glycoprotein or α2-HS-glycoprotein) is a major plasma glycoprotein predominantly synthesized in the liver. Human fetuin is named after its bovine homolog. Fetuins are found in most mammals. Human fetuin is a negative acute-phase protein; normal circulating levels in adults (300-600 µg/ml) fall significantly (30-50%) during injury and infection. The biological role of fetuin is unknown, although it has been implicated as an immunomodulator that can participate in stimulation of bacterial phagocytosis by neutrophils and promotion of endocytosis by mouse macrophages. Hepatocytes are the principal cell source of circulating fetuin, but it also is expressed by monocyte/macrophages. Fetuins occur in large amounts in blood and cerebrospinal fluid and accumulate to high concentrations in calcified bone. The fetuin promoter region has several potential interleukin 6-responsive elements, and its synthesis is down-regulated during injury and inflammation. Fetuin is an acidic glycoprotein with three Nlinked and three O-linked oligosaccharide chains, whose terminal sugar residues are rich in sialic acid (Nacetylneuraminic acid), contributing to its net negative charge. A role for fetuin as a carrier of bioactive molecules has been proposed based on observations that it binds and carries Ca2+ ion. Fetuin is implicated in bone remodeling, immune function and may play a role in tumor progression of certain cell types. Fetuin plays a role as an anti-inflammatory agent by suppressing the release of TNF from stimulated macrophages. Fetuin also interacts with members of the matrix metalloprotease family of zinc dependent secreted transmembrane proteins that degrade basement membranes and extracellular matrix components. The biological activity of fetuin is mediated through its direct interaction with other proteins. Fetuin down-regulates a number of receptor tyrosine kinase family members. A motif within fetuin has homology to the TGF-β receptor type II. Circulating human plasma fetuin is partly phosphorylated which implies that phosphorylated fetuin may have a physiological function in vivo. Human fetuin isolated from plasma is a two-chain molecule consisting of a A-chain of 322 amino acid residues (53 kDa) and a B-chain of 27 residues (5 kDa). The carboxy terminal 40 amino acids of the A chain constitute a bridging peptide that may be removed proteolytically in vivo. A single mRNA encodes both the A and B chains. The apparent molecular weight of intact human fetuin is 58 kDa.

General readings

Schäfer C. et al. (2003) The serum protein á2?Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J. Clin. Invest. 112:357-366.
Leite-Browning, M.L. et al. (2002) Interactions of 2-HS-glycoprotein (fetuin) with MMP-3 and mutine squamous cell carcinoma cells. Intl. J. Onc. 21: 965-971.
Nawratil, P. et al. (1996) Limited proteolysis of human á2-HS glycoprotein/Fetuin. J. Biol. Chem 271:49, 31735-31741.
Kazi J.A. et al. (1998) Changes with age of the rat fetuin concentration in serum and its mRNA expression. J Biochem (Tokyo) 124(1):179-86.
Ohnishi, T. et al. (1997) Effect of phosphorylated rat fetuin on the growth of hepatocytes in primary culture in the presence of human hepatocyte-growth factor. Evidence that phosphorylated fetuin is a natural modulator of hepatocyte-growth factor. Eur J Biochem. 243(3):753-61.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Alpha-2-HS-glycoprotein / AHSG antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-AHSG mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504670) Mouse IgG1 OTI2H2 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Alpha-2-HS-glycoprotein / AHSG (C-term) antibody

AHSG antibody (C-term) (Cat. #AP50120PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the AHSG antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Alpha-2-HS-glycoprotein / AHSG antibody

WB of Fetuin. Anti-Human Fetuin antibody, generated by immunization with mature protein, was tested by WB against fetuin in purified preparations and in human plasma. Lane 1 contains 250 ng of purified human fetuin. Lane 2 contains 5 ul of a 1:50 dilution of human serum. Dilution of Anti-Human Fetuin antibody between 1:10,000 and 1:20,000 showed strong reactivity by WB. In this blot the antibody was used at a 1:10,000 dilution. Goat Purified Hu E, WB
0.5 mg / €325.00
  OriGene Technologies, Inc.

Alpha-2-HS-glycoprotein / AHSG antibody

AHSG antibody (0.5µg/ml) staining of Human albunin-depleted Serum (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Alpha-2-HS-glycoprotein / AHSG antibody

Western blot analysis of extracts of various cell lines, using AHSG antibody. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Alpha-2-HS-glycoprotein / AHSG antibody

WB Suggested Anti-AHSG Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: Human Liver Rabbit IgG Purified Can, Eq, GP, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Alpha-2-HS-glycoprotein / AHSG antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Goat Purified Hu E, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Alpha-2-HS-glycoprotein / AHSG antibody

Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Sheep Hu E, P
0.25 mg / €470.00
  Acris Antibodies GmbH

Alpha-2-HS-glycoprotein / AHSG antibody

Alpha-2-HS-glycoprotein / AHSG Rabbit Aff - Purified Hu C, E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Alpha-2-HS-glycoprotein / AHSG antibody

Alpha-2-HS-glycoprotein / AHSG Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

AHSG MaxPab polyclonal antibody. Western Blot analysis of AHSG expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

AHSG MaxPab polyclonal antibody. Western Blot analysis of AHSG expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

Western Blot analysis of AHSG expression in transfected 293T cell line (H00000197-T01) by AHSG MaxPab polyclonal antibody.

Lane 1: AHSG transfected lysate(39.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

AHSG MaxPab rabbit polyclonal antibody. Western Blot analysis of AHSG expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

Detection limit for recombinant GST tagged AHSG is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 5D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

Alpha-2-HS-glycoprotein / AHSG Mouse IgG1 1D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

Alpha-2-HS-glycoprotein / AHSG Hu
0.1 mg / €560.00
  Abnova Taiwan Corp.

Alpha-2-HS-glycoprotein / AHSG antibody

Human Liver; WB Suggested Anti-AHSG Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Human Liver; AHSG antibody - N-terminal region (ARP33815_P050) in Human Liver cells using Western Blot Rabbit Aff - Purified Can, Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Alpha-2-HS-glycoprotein / AHSG antibody

Alpha-2-HS-glycoprotein / AHSG Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

Alpha-2-HS-glycoprotein / AHSG antibody

Alpha-2-HS-glycoprotein / AHSG Sheep IgG Purified Bov E
0.5 ml / €340.00
  Novus Biologicals Inc.

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