Alpha-2B adrenergic receptor antibody

Principal name

Alpha-2B adrenergic receptor antibody

Alternative names for Alpha-2B adrenergic receptor antibody

ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor

SwissProt ID

P18089 (Human), P19328 (Rat), P30545 (Mouse)

Gene ID

24174 (Adra2b), 151 (ADRA2B)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of Alpha-2B adrenergic receptor antibody

Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adreline and noradreline (called epinephrine and norepinephrine in the United States). Adreline and noradreline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.The Adrenoceptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: a1, a2 and Ã?-Adrenoceptors. Each type is further divided into at least three subtypes: a1A, a1B, a1D, a2A, a2B, a2C, Ã?1, Ã?2, Ã?3. The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system.The a2B-Adrenoceptor has a distinct pattern of expression within the brain, liver lung and kidney, and recent studies using the knock out mouse system have shown that disruption of this receptor indeed affects mouse viability, blood pressure responses to a2-Adrenoceptors agonists and the hypertensive response to salt loading.Like the a2A-Adrenoceptor subtype, the a2B-Adrenoceptor undergoes short term agonist promoted desensitization5. This desensitization is due to the phosphorylation of the receptor by G-protein coupled receptor kises (GRKs)6 which ultimately promotes uncoupling of the receptor from the G-protein subunit.

General readings

1. Ozawa, Y, et al. Alpha2-adrenergic receptor subtype alterations in the brainstem in the sudden infant death syndrome. Early Hum Dev 2003, 75 Suppl, S129-38
2. Yun, J., et al. Gene expression profile of neurodegeneration induced by alpha1B-adrenergic
receptor overactivity: NMDA/GABAA dysregulation and apoptosis. Brain 2003, Pt 12, 2667-81
3. Peterhoff, M., et al. Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice. Eur. J. Endocrinol 2003, 4, 343-50
4. Paris, A., et al. Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology 2003, 99, 4, 889-95
5. Brady, AE, et al. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. J Biol Chem 2003, 278, 34, 32405-12
6. Savola, JM, et al. Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that
reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord 2003, 8, 872-83
7. Sivenius, K, et al. A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous
function in central obesity. Obes Res 2003, 8, 962-70
8. Ge, H, et al. Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-
adrenoceptor. Biochem Biophys Res Commun 2003, 306, 4, 959-65
9. Sykiotis GP, et al. The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity. Clin Auton Res 2003, 3, 203-7
10. Feldman J, Bousquet P. Role of cental alpha2B-adrenergic receptors in blood pressure control and hypertension. J Hypertens 2003, 5, 871-2
11. Willems EW, et al. Possible role of alpha-adrenoceptor subtypes in acute migraine therapy.
Cephalalgia 2003, 4, 245-57

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Alpha-2B adrenergic receptor / ADRA2B antibody

Formalin-fixed and paraffin-embedded human breast carcinoma with ADRA2B Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Alpha-2B adrenergic receptor / ADRA2B antibody

Alpha-2B adrenergic receptor / ADRA2B Rabbit IgG Purified Hu ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-2B adrenergic receptor / ADRA2B antibody

Western blot analysis of rat kidney (lanes 1 and 5), lung (lanes 2 and 6), liver (lanes 3 and 7) lysates and rat skeletal muscle membranes (lanes 4 and 8): 1. Anti-a2B-Adrenoceptor (extracellular) antibody, (1:200). 2. Anti-a2B-Adrenoceptor  (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt P, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Alpha-2B adrenergic receptor / ADRA2B antibody

Figure 1. Western blot analysis using AM05339PU-N ADRA2B antibody on MDCK cells transfected to produce alpha2B receptor protein. Mouse IgG1 5G10 Purified Ms, Rt C, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

Alpha-2B adrenergic receptor / ADRA2B antibody

Western blot analysis of Adra2b expression in MDCK cells transfected to produce Adra2b protein with Adra2b monoclonal antibody, clone 5G10. Mouse IgG1 5G10 Ms, Rt C, WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

Alpha-2B adrenergic receptor / ADRA2B antibody

Immunofluorescence analysis of HepG2 cells, using Adrenergic Receptor alpha-2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €205.00
  Assay Biotech

Alpha-2B adrenergic receptor / ADRA2B antibody

Immunofluorescence analysis of HepG2 cells, using Adrenergic Receptor alpha-2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

Alpha-2B adrenergic receptor / ADRA2B antibody

Alpha-2B adrenergic receptor / ADRA2B Rabbit IgG Aff - Purified Hu E, ICC/IF
0.1 mg / €360.00
  Novus Biologicals Inc.

Alpha-2B adrenergic receptor / ADRA2B antibody

Alpha-2B adrenergic receptor / ADRA2B Rabbit IgG Aff - Purified Hu E, ICC/IF
50 µg / €290.00
  Novus Biologicals Inc.

9 Item(s)

per page
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