Alpha-actinin-2 / ACTN2 antibody

Principal name

Alpha-actinin-2 / ACTN2 antibody

Alternative names for Alpha-actinin-2 / ACTN2 antibody

Alpha actinin skeletal muscle isoform 2, F-actin cross-linking protein

SwissProt ID

P20111 (Chick), P35609 (Human), Q2YDR5, Q3ZC55 (Bovin), Q9JI91 (Mouse)

Gene ID

88 (ACTN2), 11472 (Actn2)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Can (Canine), Chk (Chicken), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP)

Background of Alpha-actinin-2 / ACTN2 antibody

The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in posttal skeletal muscle, suggesting independent functiolpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and alogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-39 DC378038.1 17-55 40-2961 BC051770.1 1-2922 2962-3458 CB153006.1 65-561 3459-3637 AL359185.25 28531-28709 3638-4210 M86406.1 3609-4181 4211-4528 AL359185.25 29283-29600

General readings

1. Verhaart IE  et al. The Dynamics of Compound, Transcript, and Protein Effects After Treatment With 2OMePS Antisense Oligonucleotides in mdx Mice. Mol Ther Nucleic Acids 3:e148 (2014). WB .
2. Giudice J  et al. Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nat Commun 5:3603 (2014). WB ; Mouse .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Alpha-actinin-2 / ACTN2 (11-347) antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Alpha-actinin-2 / ACTN2 (215-500) antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Alpha-actinin-2 / ACTN2 antibody

  Rabbit polyclonal Actinin alpha-2/3 antibody  
Western blot analysis of extracts from HeLa cells, HepG2 cells and HUVEC cells, using Actin a-2/3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-2 / ACTN2 antibody

  Rabbit Polyclonal Anti-ACTN2 Antibody  
WB Suggested Anti-ACTN2 Antibody Titration: 0.625 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Muscle Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-2 / ACTN2 antibody

  Rabbit Polyclonal Anti-ACTN2 Antibody  
WB Suggested Anti-ACTN2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-2 / ACTN2 antibody

  Rabbit Polyclonal Anti-ACTN2 Antibody  
WB Suggested Anti-ACTN2 Antibody Titration: 1.25 ug/ml; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-2 / ACTN2 antibody

  Rabbit Polyclonal Anti-Actinin a 2/3 Antibody  
Western blot analysis of Actinin a 2/3 expression in HeLa cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-2 / ACTN2 antibody

  Rabbit Polyclonal Anti-ACTN2 Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Mouse heart tissue, Mouse muscle tissue, Primary antibody: (ACTN2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-2 / ACTN2 (C-term) antibody

ACTN2 Antibody (C-term) (Cat. #AP50071PU-N) western blot analysis in mouse heart tissue lysates (35µg/lane).This demonstrates the ACTN2 antibody detected the ACTN2 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Alpha-actinin-2 / ACTN2 antibody

Alpha-actinin-2 / ACTN2 Mouse IgG1 EA-53 Supernatant Hu C, P
1 ml / €480.00
  Acris Antibodies GmbH

Alpha-actinin-2 / ACTN2 antibody

Alpha-actinin-2 / ACTN2 Mouse IgG1 EA-53 Supernatant Hu C, P
0.5 ml / €320.00
  Acris Antibodies GmbH

Alpha-actinin-2 / ACTN2 antibody

Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using Actinin alpha-2/3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

Alpha-actinin-2 / ACTN2 antibody

Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using Actinin alpha-2/3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

ACTN2 - human gene knockout kit via CRISPR

ACTN2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ACTN2 - human gene knockout kit via CRISPR

ACTN2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ACTN2 - human gene knockout kit via CRISPR

ACTN2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ACTN2 - human gene knockout kit via CRISPR

ACTN2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Actn2 - mouse gene knockout kit via CRISPR

Actn2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Actn2 - mouse gene knockout kit via CRISPR

Actn2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Actn2 - mouse gene knockout kit via CRISPR

Actn2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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