Alpha-actinin-4 / ACTN4 antibody

Principal name

Alpha-actinin-4 / ACTN4 antibody

Alternative names for Alpha-actinin-4 / ACTN4 antibody

Non-muscle alpha actinin 4, F-actin cross-linking protein

SwissProt ID

A5D7D1 (Bovin), O43707 (Human), P57780 (Mouse), Q90734 (Chick), Q9QXQ0 (Rat)

Gene ID

81 (ACTN4), 60595 (Actn4), 63836

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, GP (Guinea Pig), Por (Porcine), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C)

Background of Alpha-actinin-4 / ACTN4 antibody

Alpha actinins belong to the spectrin superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in its gene have been associated with focal and segmental glomerulosclerosis.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

General readings

Celli L. et al. Evidence of a Functional Role for Interaction between ICAM-1 and Nonmuscle -Actinins in Leukocyte Diapedesis. The Journal of Immunology; 2006, 177: 4113-4121.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Actinin-4 Splice Variant antibody

Actinin-4 Splice Variant Mouse 15H2 Purified Hu P, WB
50 µg / €760.00
  Funakoshi Co., Ltd.

Alpha-actinin-4 / ACTN4 antibody

  Rabbit Polyclonal antibody to alpha Actinin 4 (actinin, alpha 4)  
Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308476 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-4 / ACTN4 antibody

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 4D10 Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Alpha-actinin-4 / ACTN4 antibody

Immunoperoxidase of monoclonal antibody to ACTN4 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG2a 4D10 Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

  Rabbit polyclonal anti-ACTN4 antibody  
Western blot analysis of extracts from 293 cells, HeLa cells and A549 cells, using ACTN4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-4 / ACTN4 antibody

  Rabbit Polyclonal Anti-ACTN4 Antibody  
Lanes: Lane1: 10 ug ACTN1-GFP transfected COS-7 lysate; Lane2: 10 ug ACTN2-GFP transfected COS-7 lysate; Lane3: 10 ug ACTN3-GFP transfected COS-7 lysate; Lane4: 10 ug ACTN4-GFP transfected COS-7 lysate; Primary Antibody Dilution: 1: 1000; Secondary Antibody: Anti-rabbit HRP; Secondary Antibody Dilution: 1: 5000; Gene Name: ACTN4; Submitted by: Johannes W. Hell, University of California; Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-4 / ACTN4 antibody

  Rabbit Polyclonal Anti-ACTN4 Antibody  
Lanes: Lane1: 10 ug ACTN1-GFP transfected COS-7 lysate; Lane2: 10 ug ACTN2-GFP transfected COS-7 lysate; Lane3: 10 ug ACTN3-GFP transfected COS-7 lysate; Lane4: 10 ug ACTN4-GFP transfected COS-7 lysate; Primary Antibody Dilution: 1: 1000; Secondary Antibody: Anti-rabbit HRP; Secondary Antibody Dilution: 1: 5000; Gene Name: ACTN4; Submitted by: Johannes W. Hell, University of California; Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Alpha-actinin-4 / ACTN4 (N-term) antibody

Immunohistochemistry on breast carcinoma Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Alpha-actinin-4 / ACTN4 (C-term) antibody

(LEFT) Western blot analysis of ACTN4 Antibody (C-term) in HepG2 cell line lysates (35ug/lane). ACTN4(arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of anti-ACTN4 Antibody (C-term) in mouse bladder tissue lysates (35ug/lane). ACTN4(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between ACTN4 and CTNNB1. HeLa cells were stained with anti-ACTN4 rabbit purified polyclonal 1:1200 and anti-CTNNB1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG2a 4D10 Ascites Hu, Ms, Rt E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG2a 1E10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG1 8G12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG1 8G4 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG1 8C1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG1 7F1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG1 3G12 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Alpha-actinin-4 / ACTN4 antibody

Alpha-actinin-4 / ACTN4 Mouse IgG1 1F8 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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