Alpha-Internexin antibody

Principal name

Alpha-Internexin antibody

Alternative names for Alpha-Internexin antibody

Alpha-Inx, INA, NEF5, NF66, 66 kDa neurofilament protein, Neurofilament-66

SwissProt ID

P23565 (Rat), P46660 (Mouse), Q08DH7 (Bovin), Q16352 (Human)

Gene ID

9118 (INA), 532236, 24503 (Ina)

Available reactivities

Mam (Mammalia), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine)

Available hosts

Mouse, Chicken, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of Alpha-Internexin antibody

In mammalian CNS, five key neurol intermediate filament (NIF) proteins have been discovered which includes alpha-internexin (66 kD, I or Inexa), peripherin (57 kD), and three neurofilament (NF) proteins, which are neurofilament light (NF-L, 68 kD), medium (NF-M, 145 kD), and heavy (NF-H, 200 kD). Among NIFs, alpha-internexin is categorized as class IV NIF which is highly expressed in most neurons during development especially when they begin to differentiate and before the expression of NF triplet proteins, and it is structurally/functiolly associated with NF triplet proteins inside mature CNS neurons. Peripherin is mainly expressed in PNS and in some CNS neurons also, and alpha-internexin - peripherin self-assemble or co-assemble with neurofilament protein subunits to form filamentous structure before their translocation into the axons to become an essential constituent of shape-maintaining IF network in mature neurons. It has been recognized as one of the many proteins phosphorylated by ATM/ATR in response to D damage and has been associated with developmental, degenerative /overexpression causes neurol cell death, and inflammatory processes of CNS. Abnormal NIF accumulation is a neuropathological sigture of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, and amyotrophic lateral sclerosis. Alpha-internexin has been detected as a major component of pathological inclusions in frontotemporal dementia, also called 'neurol intermediate filament inclusion disease (NIFID).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Alpha-Internexin antibody

Western Blot: alpha Internexin Antibody [TA336609] - Western blot of whole rat spinal cord homogenate stained with RPCA-a-Int, at dilution of 1:20,000. A prominent band running at ~66kDa is apparent, as well as smaller lower bands which are apparently deg Rabbit Purified Hu, Mam, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Western blot of rat cortex lysate showing specific immunolabeling of the ~ 66k alpha internexin protein Mouse IgG1 ID2 Ig Fraction Mam C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Western blot of rat cortex lysate showing specific immunolabeling of the ~ 66k alpha internexin protein. Chicken Ig Ig Fraction Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Western blot analysis of extracts from K562 cells, using INA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Predicted band size: 55 kDa. Positive control: Mouse brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Predicted band size: 55 kDa. Positive control: Mouse brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/550 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 3 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Predicted cell location: Cytoplasm. Positive control: Human lung and renal cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using INA antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Predicted band size: 55 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 10%SDS-PAGE Lysate: 50 ug per lane Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

INA Antibody (Cat. #TA324344) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the INA antibody detected the INA protein (arrow). Mouse IgG1 257CT7.1.2 Purified Bov, Ms, Rt ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Western Blot: alpha Internexin Antibody (2E3) -  Neuronal Markers [TA336610] - blot of homogenate of rat facial nucleus incubated with NBP1-05206, which reveals a single clean band running at approx. 66kDa. Mouse IgG1 2E3 Purified Bov, Hu, Ms, Por, Rt C, ICC/IF, P, WB
0.5 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Immunocytochemistry/Immunofluorescence: alpha Internexin Antibody (1D2) [TA336618] - Mixed cultures of rat CNS cells stained with TA336618 (red) and chicken antibody to Microtubule associated protein 2 (MAP2- green). The a-internexin is localized primaril Mouse IgG1 1D2 Purified Hu, Mam, Ms, Rt C, P, WB
0.5 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Western Blot: alpha Internexin Antibody (2E4) [TA337202] - Analysis of alpha-internexin/NF66 (clone 2E3) in crude homogenates of rat facial nucleus. Image kindly provided by G. Shaw of Florida University. Mouse IgG1 2E4 Purified Hu, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Internexin antibody

Alpha-Internexin Mouse IgG 1D2 Mam ICC/IF, WB
0.2 ml / €340.00
  Acris Antibodies GmbH

Alpha-Internexin antibody

Alpha-Internexin Rabbit IgG Liquid Mam C, ICC/IF, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Alpha-Internexin antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with INA antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Alpha-Internexin antibody

Alpha-Internexin Chicken Ig Liquid Hu, Ms, Rt ICC/IF, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Alpha-Internexin antibody

Mixed cultures of rat CNS cells stained with Ina monoclonal antibody, clone 1D2 ( Cat # MAB2316 ) ( red ) and chicken antibody to Microtubule associated protein 2 ( MAP2- green ). The a-internexin is localized primarily in neuronal axons in these cultures, while the perikarya and dendrites of neurons stain strongly for MAP2. Mouse 1D2 Hu C, ICC/IF, P, WB
0.5 ml / €560.00
  Abnova Taiwan Corp.

Alpha-Internexin antibody

Alpha-Internexin Rabbit Hu ICC/IF, P, WB
50 µl / €560.00
  Abnova Taiwan Corp.

Alpha-Internexin antibody

Alpha-Internexin Rabbit IgG Bov ICC/IF, WB
0.1 ml / €560.00
  Abnova Taiwan Corp.

Alpha-Internexin antibody

Western blot of whole rat spinal cord homogenate stained with Ina polyclonal antibody ( Cat # PAB14168 ), at dilution of 1 : 20,000.
A prominent band running at ~ 66kDa is apparent, as well as smaller lower bands which are apparently degradation products.
A minor band at ~ 150kDa is also seen, apparently resulting from dimerization of alpha-internexin. Rabbit Rt C, E, ICC/IF, WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

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