Alpha-Synuclein / SNCA antibody

Principal name

Alpha-Synuclein / SNCA antibody

Alternative names for Alpha-Synuclein / SNCA antibody

NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor

SwissProt ID

O55042 (Mouse), P37377 (Rat), P37840 (Human), Q3T0G8 (Bovin)

Gene ID

6622 (SNCA), 29219 (Snca), 20617

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Mky (Monkey), Por (Porcine), Mam (Mammalia), Chk (Chicken), Sh (Sheep), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat, Sheep, Chicken

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), ELISA (detection) (E(detection)), Radioimmunoassay (R), EPair for Elisa (EPair), Dot blot (Dot)

Background of Alpha-Synuclein / SNCA antibody

Alpha-Synuclein is a member of the synuclein family, the other two proteins being beta and gamma synuclein. Alpha-Synuclein was origilly isolated as a major syptic vesicle associated protein from the electric organ of the fish Torpedo. Direct homologues of alpha-Synuclein are found in all vertebrates. Later work connected alpha-Synuclein with human brain pathology, when a protein origilly identified as a component of C, the "Non-Amyloid beta Component of Alzheimer's disease amyloid" proved to be a peptide derived from alpha-Synuclein. The alpha-Synuclein protein is therefore sometimes known as C precursor or CP. Further work showed that alpha-Synuclein is a major component of the Lewy bodies of Parkinson's disease and point mutations of alpha-Synuclein proved to be causative of some forms of familial Parkinson's disease. However, despite being discovered as a component of amyloid preparations, alpha-Synuclein is apparently not a major component of the senile plaques of Alzheimer's disease. Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha-Synuclein genes. Alpha-Synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS). Alpha-Synuclein is heavily expressed in brain and appears to be localized primarily to presyptic regions, though not with a typical syptic vesicle distribution pattern. The synuclein proteins appear to have little 3D structure in solution, and probably belong to the family of "intrinsically unstructured proteins" which only adopt a well-defined conformation when bound to other proteins or membrane lipids.

General readings

Jakes, R., et al. (1994) FEBS lett. 345, 27-32
Ueda, K., et al. (1993) Proc. Natl.Acad. Sci. USA 90, 11282-11286
Kim, J. (1997) Molecules and Cells 7, 78-83
Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344, 325-334.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Alpha-Synuclein / SNCA antibody

Human brain stained with Anti-alpha-Synuclein antibody Rabbit Purified Hu, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA antibody

Human brain stained with Anti-alpha-Synuclein antibody Rabbit Purified Hu, Rt P
1 ml / €440.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA antibody

Human brain stained with Anti-alpha-Synuclein antibody Rabbit Purified Hu, Rt P
0.1 ml / €180.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA antibody

AP32035PU-N Alpha-Synuclein / SNCA Antibody staining of Human Amygdala (A) and fetal Mouse (B) Brain lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (NACP140) antibody

AP32036PU-N Alpha-Synuclein / SNCA Antibody staining of Human Amygdala lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Por WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA antibody

Western blot of a rat brain lysate showing specific immunolabeling of the ~15k alpha synuclein protein Mouse IgG1 3H9 Ascites Hu, Mam, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western blot analysis of extracts from 293 cells, treated with Etoposide 25µM 60', using Synuclein-alpha (Ab-133) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western blot analysis of extracts from rat heart, using Synuclein-pan antibody (#TA311770).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Predicted band size: 14 kDa . Positive control: Mouse Brain tissue lysate. Recommended dilution: 1/ 500-1000. (Gel: 12%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western blot analysis of Synuclein expression in HuvEc whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Alpha-Synuclein / SNCA Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western blot analysis on mouse brain cell lysate using Alpha-synuclein Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western Blot: alpha-Synuclein Antibody (2A7) [TA336706] - Blots of TA336706 on recombinant alpha-synuclein (left lane) and crude extract of mouse brain (right lane, courtesy Rogan Tinsley, Howard Florey Institute, University of Melbourne). Mouse IgG1 2A7 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western Blot: alpha-Synuclein [Nitrate Tyr125, Nitrate Tyr133] Antibody (24.8) [TA336747] - Western blot of (A) Nitrated alpha-Synuclein protein and (B) non-nitrated alpha-Synuclein protein. Mouse IgG1 24.8 Purified Hu, Ms C, F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western Blot: alpha-Synuclein Antibody (3H9) [TA336858] - WB validation of TA336858 on recombinant alpha-synuclein (left lane) and crude extract of mouse brain (right lane) Mouse IgG1 3H9 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western Blot: alpha-Synuclein Antibody [TA337099] - Crude extract of rat brain, showing strong band at 15 kDa. Chicken Purified Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Western blot analysis of SNCA in mouse cerebellum tissue lysate with SNCA antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Alpha-Synuclein / SNCA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SNCA mouse monoclonal antibody. (TA506533) Mouse IgG2b OTI2F6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Alpha-Synuclein / SNCA antibody

Alpha-Synuclein / SNCA Mouse IgG1 4D6 Purified Hu C, E, P, WB
0.2 ml / €1,040.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA antibody

Extracts of SHSY-5Y human neuroblastoma cells were resolved by SDS PAGE and transferred to a PVDF membrane. Membranes were incubated with 1 μg/mL of the anti-α synuclein antibody (Syn 211). After washing, membranes were incubated with goat F(ab’)2 anti Mouse IgG alkaline phosphatase diluted 1:5000 and the membrane was incubated with CDP-Substrate using the WesternStarTM method (Tropix). The membrane was then exposed to Kodak BioMax film. Mouse IgG1 Syn 211 Purified Hu C, E, WB
0.1 mg / €590.00
  Acris Antibodies GmbH

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