Alpha-Synuclein / SNCA antibody

Principal name

Alpha-Synuclein / SNCA antibody

Alternative names for Alpha-Synuclein / SNCA antibody

NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor

SwissProt ID

O55042 (Mouse), P37377 (Rat), P37840 (Human), Q3T0G8 (Bovin)

Gene ID

6622 (SNCA), 29219 (Snca), 20617

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Mky (Monkey), Por (Porcine), Chk (Chicken), Sh (Sheep), Rb (Rabbit), Mam (Mammalia)

Available hosts

Mouse, Rabbit, Goat, Sheep, Chicken

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), ELISA (detection) (E(detection)), Radioimmunoassay (R), EPair for Elisa (EPair), Dot blot (Dot), Immunoelectron Microscopy (EM)

Background of Alpha-Synuclein / SNCA antibody

Alpha-synuclein is expressed principally in the central nervous system (brain) but is also expressed in low concentrations in a variety of tissues except liver. It is predominantly expressed in the neocortex, hippocampus, substantia nigra, thalamus, and cerebellum of the CNS. It is primarily a neuronal protein, but can also be found in the neuroglial cells. It is concentrated in presynaptic nerve terminals of neurons, as well as having reported nuclear and mitochondrial localization. Alpha-synuclein interacts with plasma membrane phospholipids. Alpha-synuclein in solution is considered to be an intrinsically disordered protein and thus lacks a stable secondary or tertiary structure. However, data suggests the presence of partial alpha helical as well as beta sheet structures as well as mostly structured tetrameric states in solution, the equilibrium of which may be altered by binding partners. The human alpha-synuclein protein is made of 140 amino acids, encoded by the SNCA gene. The primary structure is divided in three distinct domains: (1-60) - An amphipathic N-terminal region dominated by four 11-residue repeats including the consensus sequence KTKEGV. This sequence has a structural alpha helix propensity similar to apolipoproteins-binding domains. (61-95) - a central hydrophobic region which includes the non-amyloid- beta; component (NAC) region, involved in protein aggregation. (96-140) - a highly acidic and proline-rich region. At least three isoforms of synuclein are produced through alternative splicing. The most common form of the protein, is the full 140 amino acid-long transcript. Other isoforms are alpha-synuclein-126, lacking residues 41-54; and alpha-synuclein-112, which lacks residues 103-130. a-synuclein may be involved in the regulation of dopamine release and transport and also may function to induce fibrillization of microtubule-associated protein tau. alpha-synuclein functions as a molecular chaperone in the formation of SNARE complexes. In particular, it can bind to phospholipids of the plasma membrane and to synaptobrevin-2 via its C-terminus domain to influence synaptic activity. alpha-synuclein is essential for normal development of the cognitive functions and that it significantly interacts with tubulin. It also reduces neuronal responsiveness to various apoptotic stimuli, leading to decreased caspase-3 activation. Alpha-synuclein fibrils are major substituent of the intracellular Lewy bodies seen in Parkinson rsquo;s disease. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.

General readings

1. Jakes, R., et al. (1994) FEBS lett. 345:27-32.
2. Ueda, K., et al. (1993) Proc. Natl.Acad. Sci. USA 90:11282-11286.
3. Kim, J. (1997) Molecules and Cells 7:78-83.
4. Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344:325-334.

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Alpha-Synuclein / SNCA (1-140) antibody

Detect alpha synuclein using antibody 4H11 at 1:5000 (5µg/ml) dilution Mouse IgG1 4H11 Aff - Purified Hu WB
0.5 mg / €420.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140) antibody

Detect alpha synuclein using antibody 4C1 at 1:1000 (5µg/ml dilution). Mouse IgG2a 4C1 Aff - Purified Hu WB
0.5 mg / €420.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140) antibody

Detects alpha-synuclein using antibody 4B4 at 1:1000 (10µg/ml) dilution. Mouse IgG2a 4B4 Aff - Purified Hu WB
0.5 mg / €420.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140) antibody

Detect alpha synuclein using antibody 8F12 at 1:500 (5µg/ml) dilution. Mouse IgG2a 8F12 Aff - Purified Hu WB
0.5 mg / €420.00
  Acris Antibodies GmbH

Alpha-Synuclein / SNCA (1-140) antibody

Detect alpha synuclein using antibody 9A9 at 1:500 (5µg/ml) dilution. Mouse IgG1 9A9 Aff - Purified Hu WB
0.5 mg / €420.00
  Acris Antibodies GmbH

5 Item(s)

per page
  • LinkedIn