alpha Tubulin / TUBA1A / TUBA3 antibody

Principal name

alpha Tubulin / TUBA1A / TUBA3 antibody

Alternative names for alpha Tubulin / TUBA1A / TUBA3 antibody

Tubulin alpha-1A chain, Tubulin B-alpha-1, Tubulin alpha-3 chain, Alpha-tubulin 3

SwissProt ID

P02550 (Pig), P68369 (Mouse), P68370 (Rat), Q71U36 (Human)

Gene ID

7846 (TUBA1A), 22142 (Tuba1a), 64158

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey), Dros (Drosophila), Mam (Mammalia), Ye (Yeast), Bov (Bovine), Chk (Chicken), GP (Guinea Pig), Por (Porcine), Xen (Xenopus)

Available hosts

Mouse, Rabbit, Chicken, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C)

Background of alpha Tubulin / TUBA1A / TUBA3 antibody

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predomintly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neurol migration. Altertive splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].

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