Amphiregulin antibody

Principal name

Amphiregulin antibody

Alternative names for Amphiregulin antibody

CRDGF, AREG, SDGF, Colorectum cell-derived growth factor, Schwannoma-Derived Growth Factor

SwissProt ID

P15514 (Human), P24338 (Rat), P31955 (Mouse)

Gene ID

374 (AREG), 11839 (Areg), 727738 (AREGB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Chicken, Rat

Available applications

Immunoprecipitation (IP), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Amphiregulin antibody

The mature secreted form of amphiregulin is an 84-amino acid residue glycosylated polypeptide which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR; these are EGF, TGFa, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds.
Amphiregulin expression is induced by phorbol ester, estrogen, androgen, and other EGFR ligands. In vitro, amphiregulin functions as an autocrine growth stimulator to drive proliferation of colon carcinoma cells, normal and oncogene-transformed mammary epithelial cells, cervical carcinoma cells, prostate cancer cells, and keratinocytes. Amphiregulin is important in the development of human placenta and murine mammary gland. It is reportedly overexpressed in human cancers of breast, colon, stomach and pancreas.

General readings

1. Johnson G R, et al. (1992) J Cell Biol 118:741-751
2. Johnson G R, et al. (1993) J Biol Chem 268:18835-
18843
3. Johnson G R and Wong L. (1994) J Biol Chem 269:
27149-27154
4. Martinez-Lacaci I et al. (1995) Endocrinology,
136:3983-3992
5. Lucia Schuger; et al. (1996) Development, 122:1759-
1767.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Amphiregulin antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-AREG Rabbit Polyclonal antibody. (TA590091) Rabbit IgG Purified Can, Hu, Mky E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Amphiregulin antibody

Western blot analysis of extracts of various cell lines, using AREG antibody. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Amphiregulin antibody

Western Blot analysis of AREG expression in transfected 293T cell line (H00000374-T01) by AREG MaxPab polyclonal antibody.

Lane 1: AREG transfected lysate(27.83 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Amphiregulin antibody

Amphiregulin Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Amphiregulin antibody

Western Blot analysis of AREG expression in transfected 293T cell line (H00000374-T03) by AREG MaxPab polyclonal antibody.

Lane 1: AREG transfected lysate(27.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Amphiregulin antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between CCND3 and AREG. HeLa cells were stained with anti-CCND3 rabbit purified polyclonal 1:1200 and anti-AREG mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2b 3E4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Amphiregulin antibody

Amphiregulin Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Amphiregulin antibody

Western Blot: Amphiregulin Antibody [NB600-543] - Western Blot analysis of Native Amphiregulin purified from Human Cells. Rabbit Purified Hu, Ms IP
0.5 ml / €400.00
  Novus Biologicals Inc.

Amphiregulin antibody

Amphiregulin Rabbit Purified Hu, Ms P
50 µg / €480.00
  Novus Biologicals Inc.

Amphiregulin antibody

Immunohistochemistry-Paraffin: Amphiregulin Antibody [NBP1-87071] - Immunohistochemistry-Paraffin: Amphiregulin Antibody [NBP1-87071] Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction center. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Amphiregulin

Amphiregulin Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 50 µg / €199.00

Special Price: 50 µg / €139.00

  OriGene Technologies, Inc.

Amphiregulin (98aa)

Amphiregulin Human > 95 % pure by SDS-PAGE gel and HPLC analyses. E. coli
50 µg / €220.00
  Acris Antibodies GmbH

Amphiregulin (98aa)

Amphiregulin Human > 95 % pure by SDS-PAGE gel and HPLC analyses. E. coli
10 µg / €140.00
  Acris Antibodies GmbH

Amphiregulin

Amphiregulin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Amphiregulin

Amphiregulin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Amphiregulin

Amphiregulin Human
50 µg / €330.00
  Abnova Taiwan Corp.

ELISA Kits

Catalog No.    

Areg (Mouse) ELISA Kit

Areg (Mouse) ELISA Kit  
1 kit / €590.00
  Abnova Taiwan Corp.

Human Amphiregulin ELISA Kit

Representative Standard Curve  
96 Tests / €450.00
  Cohesion Biosciences Ltd.

Lysates

Catalog No.    

Amphiregulin Lysate(Denatured)

Amphiregulin Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Amphiregulin Lysate(Denatured)

Amphiregulin Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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