Amyloid A Component antibody

Principal name

Amyloid A Component antibody

Alternative names for Amyloid A Component antibody

AA-Type Amyloidosis, APO SAA, APO-SAA

Available reactivities

Hu (Human)

Available hosts

Mouse

Available applications

Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of Amyloid A Component antibody

The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "housekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis. Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils, which are derived from different proteins. Almost all patients with amyloidosis have some level of renal disorders. The immunoperoxidase technique has the advantage of being able to detect amyloid in formalin-fixed paraffin embedded tissues and is a very specific method for identifying amyloid fibril proteins. Small and minute amounts of amyloid can be detected with both Amyloid P (ab688) and Amyloid A antibodies, and thus could allow earlier treatment before organ damage has occurred.

General readings

General / background references:Hazenberg BP et al. A quantitative method for detecting deposits of amyloid A protein in aspirated fat tissue of patients with arthritis. Ann Rheum Dis 58:96-102 (1999). PubMed PMID: 10343524
Wilkins J et al. Rapid automated enzyme immunoassay of serum amyloid A. Clin Chem 40:1284-90 (1994). PubMed PMID: 8013100

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Amyloid A Component antibody

Amyloid A Component Mouse IgG2a Reu 86.2 Supernatant Hu C, E, P
1 ml / €320.00
  Acris Antibodies GmbH

Amyloid A Component antibody

Amyloid A Component Mouse IgG2a mc1 Supernatant Hu P
1 ml / €440.00
  Acris Antibodies GmbH

Amyloid A Component antibody

Amyloid A Component Mouse IgG2a mc1 Supernatant Hu P
0.5 ml / €300.00
  Acris Antibodies GmbH

Amyloid A Component antibody

Amyloid A Component Mouse IgG2a mc1 Serum Hu C, P
1 ml / €340.00
  Novus Biologicals Inc.

Amyloid A Component antibody

Amyloid A Component Mouse IgG1 Reu86.5 Purified Hu C, E, P
0.5 ml / €510.00
  Novus Biologicals Inc.

5 Item(s)

per page
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