Amyloid beta A4 protein / APP antibody

Principal name

Amyloid beta A4 protein / APP antibody

Alternative names for Amyloid beta A4 protein / APP antibody

Alzheimer disease amyloid protein, Amyloid Precursor Protein, ABPP, APPI, PreA4, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II

SwissProt ID

P05067 (Human), P08592 (Rat), P12023 (Mouse), Q28053 (Bovin), Q28280 (Canfa), Q28757 (Sheep)

Gene ID

351 (APP), 54226 (App), 11820

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Chk (Chicken), Bov (Bovine), Can (Canine), Dros (Drosophila), Por (Porcine), Rb (Rabbit), African clawed frog, Ze (Zebrafish)

Available hosts

Rabbit, Goat, Mouse, Chicken

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Radioimmunoassay (R), Flow Cytometry (F), Luminex (LMNX)

Background of Amyloid beta A4 protein / APP antibody

Beta Amyloid, also known as Abeta, is a peptide that varies in length from 39 to 43 amino acids and is processed from the Amyloid precursor protein (APP). Beta Amyloid is known as the main component of amyloid plaques, which are deposits found in the brains of patients with Alzheimer's disease. The form(s) of beta Amyloid associated with the pathology characteristic of Alzheimer's disease still remains unclear. Currently, controversy exists as to the existence of intraneurol beta Amyloid. Research indicates that intraneurol beta Amyloid accumulation may be an important proximal neurotoxic event in the pathogenesis of Alzheimer's disease. Many commercially available beta Amyloid antibodies cross react with APP or APP C-termil fragments. This MOAB-2 antibody is specific for beta Amyloid but not APP. MOAB-2 is a pan-specific beta Amyloid antibody that detects uggregated, oligomeric and fibrillar forms of beta Amyloid. This is important because beta Amyloid is known to aggregate and form a variety of potentially toxic conformations. MOAB-2 displays strong extracellular beta Amyloid immunoreactivity, and so detects classic plaque pathology. MOAB-2 is selective for Abeta 42 over Abeta 40. This is also an advantage as the 42 amino acid form of beta Amyloid is likely the toxic form. MOAB-2 demonstrates strong intraneurol immunoreactivity in both human and beta Amyloid-Tg mouse tissue and has the potential to aid future research into the functiol importance of intraneurol beta Amyloid.

General readings

1. Ponte, P. et al. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331: 525 - 527.
2. Selkoe, D.J. (1994) Cell biology of the amyloid beta protein precursor and the mechanism of Alzheimer's disease. Ann. Rev. Cell. Biol. 10: 373-403.
3. Ponte, P. et al. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331: 525-527.
4. Selkoe, D.J. (1994) Cell biology of the amyloid beta protein precursor and the mechanism of Alzheimer's disease.
Ann. Rev. Cell. Biol. 10: 373-403.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Amyloid beta + APP antibody

AP31949PU-N APP antibody staining of Human Cerebral Cortex lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Por E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Amyloid beta A4 protein / APP antibody

  Rabbit Polyclonal antibody to beta Amyloid (amyloid beta (A4) precursor protein)  
Sample(30 ug of whole cell lysate). A:Hep G2. 7.5% SDS PAGE. TA308848 diluted at 1:1500 Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Amyloid beta A4 protein / APP antibody

  Rabbit polyclonal Amyloid ß A4 (Phospho-Thr743/668) antibody  
Western blot analysis of extracts from Hela cells, using Amyloid . A4 (phospho-Thr743/668) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Amyloid beta A4 protein / APP antibody

  Mouse Monoclonal beta Amyloid Antibody (MOAB-2)  
Western Blot: beta Amyloid Antibody (MOAB-2) [TA336896] - Analysis of beta Amyloid (MOAB-2) antibody in 1) 100 pmole beta Amyloid 42, 2) 5xFAD mouse brain homogenate Repetition 1 and 3) 5xFAD mouse brain homogenate Repetition 2. Mouse IgG2b MOAB-2 Purified Hu, Ms, Rt C, E, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Amyloid beta A4 protein / APP antibody

  anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI7G9 (formerly 7G9)  
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500969, Dilution 1:50) Mouse IgG1 OTI7G9 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI3D11 (formerly 3D11)  
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500970, Dilution 1:50) Mouse IgG1 OTI3D11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI9E2 (formerly 9E2)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500971, Dilution 1:50) Mouse IgG1 OTI9E2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI2B10 (formerly 2B10)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973) Mouse IgG1 OTI2B10 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI7B8 (formerly 7B8)  
Immunohistochemical staining of paraffin-embedded prostate tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500978, Dilution 1:50) Mouse IgG1 OTI7B8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI5F1 (formerly 5F1)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500991) Mouse IgG2a OTI5F1 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI6B7 (formerly 6B7)  
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500992, Dilution 1:50) Mouse IgG1 OTI6B7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI4C3 (formerly 4C3)  
Immunohistochemical staining of paraffin-embedded prostate tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501006, Dilution 1:50) Mouse IgG2a OTI4C3 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI3E3 (formerly 3E3)  
Immunohistochemical staining of paraffin-embedded prostate tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501042, Dilution 1:50) Mouse IgG1 OTI3E3 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI4C9 (formerly 4C9)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505011) Mouse IgG2b OTI4C9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI6F11 (formerly 6F11)  
Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505046) Mouse IgG2a OTI6F11 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP antibody

  APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI7B8 (formerly 7B8)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505055) Mouse IgG2a OTI7B8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Amyloid beta A4 protein / APP (C-term) antibody

  Rabbit Polyclonal Antibody against APP  
(LEFT)Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APP gene (Lane 2) (Origene Technologies). (RIGHT)Western blot analysis of APP (arrow) using rabbit polyclonal APP Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APP gene (Lane 2) Rabbit Ig Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Amyloid beta A4 protein / APP antibody

  Rabbit Polyclonal Antibody against Abeta 40  
Detection of Abeta 40 on 5 ng of peptide per lane. Lane 1: Abeta-40, lane 2: Abeta-42, lane 3: Abeta-40 and -42 mix. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Amyloid beta A4 protein / APP antibody

  Rabbit Polyclonal Antibody against Abeta 42  
Detection of Abeta 42 on 5 ng of peptide per lane using anti-Abeta 42 (lot A). Lane 1: Abeta-40, lane 2: Abeta-42, lane 3: Abeta-40 and -42 mix. Band appears at approximately 6 kDa. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Amyloid beta A4 protein / APP antibody

  Rabbit Polyclonal APP Antibody  
Western blot analysis of APP in human (A), mouse (B), and rat (C) brain tissue lysates with APP antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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