Amyloid beta antibody

Principal name

Amyloid beta antibody

Alternative names for Amyloid beta antibody

Amyloid beta peptide

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Sh (Sheep), Prim (Primate)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (capture) (E(capture)), Dot blot (Dot), Radioimmunoassay (R), ELISA (detection) (E(detection))

Background of Amyloid beta antibody

Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver; ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri; moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

General readings

1. N-terminal EFRH sequence of Alzheimer's beta-amyloid peptide represents the epitope of its anti-aggregating antibodies. (Frenkel D; J Neuroimmunol, 1998 Aug 1)
2. Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia. (Bonaiuto C; J Neuroimmunol, 1997 Jul) (Luo Y; Neurosci Lett, 1996 Oct 18)
3. Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. (Suo Z; Brain Res, 1998 Oct 5)
4. Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons. (Paradis E; J Neurosci, 1996 Dec 1)
5. Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease. (Hoshi M; J Biol Chem, 1997 Jan 24)
6.Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. (Kaltschmidt B; Proc Natl Acad Sci U S A, 1997
Mar 18)
7. Disaggregation of Alzheimer beta-amyloid by site-directed mAb. (Solomon B; Proc Natl Acad Sci U S A, 1997 Apr 15)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Amyloid beta (1-14) antibody

Immunohistochemistry-Paraffin: beta Amyloid Antibody [NBP1-78007] - Human Heart (formalin-fixed, paraffin-embedded) stained with Anti-Beta Amyloid Antibody at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €510.00
  Novus Biologicals Inc.

Amyloid beta (1-40 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2µg/ml mab bA4 (40)-5C3 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). 
Lane 1: bA4 (1-40)
Lane 2: bA4 (1-42)
Lane 3: bA4 (1-43) Mouse IgG1 5C3 Biotin Hu E, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40 specific) antibody

Amyloid beta Mouse IgG1 5C3 FITC Hu ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides were applied on SDS-PAGE and transferred to a PVDF membrane. The Immunoblot was probed with 2 µg/ml mab bA4 (40)-5C3 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). 
Lane 1: bA4 (1-40), Lane 2: bA4 (1-42), Lane 3: bA4 (1-43) Mouse IgG1 5C3 Purified Hu E, ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-40/42) antibody

Amyloid beta Mouse IgG1 9F1 Biotin Hu E, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40/42) antibody

Amyloid beta Mouse IgG1 9F1 FITC Hu ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40/42) antibody

Amyloid beta Mouse IgG1 9F1 Purified Hu E, ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-42 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2µg/ml mab bA4 (42)-8G7 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec).
Lane 1: bA4(1-40)  
Lane 2: bA4 (1-42)  
Lane 3: bA4 (1-43) Mouse IgG1 8G7 Biotin Hu E, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-42 specific) antibody

Amyloid beta Mouse IgG1 8G7 FITC Hu ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-42 specific) antibody

Figure 1. Immunoblot Analysis Amyloid beta A4 peptides: Lane 1: bA4(1-40), Lane 2: bA4 (1-42), Lane 3: bA4 (1-43) were applied on SDS-PAGE and transferred to a PVDF membrane. The Immunoblot was probed with 2 µg/ml mab bA4 (42)-8G7for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). Mouse IgG1 8G7 Purified Hu E, ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-43 specific) antibody

Amyloid beta Mouse IgG1 6G12 Biotin Hu E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-43 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides (lane 1: bA4(1-40); lane 2: bA4 (1-42); lane 3: bA4 (1-43)) were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2 µg/ml AM00004PU-N for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). Mouse IgG1 6G12 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, not APP reactive) antibody

Amyloid beta Mouse IgG1 11H3 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, APP reactive) antibody

Amyloid beta Mouse IgG1 19H5 Biotin Hu E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, APP reactive) antibody

Immunoblot Analysis: Amyloid beta A4 peptides (lane 1: bA4(1-40); lane 2: bA4 (1-42); lane 3: bA4 (1-43)) were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2µg/ml mab bA4N-19H5 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). Mouse IgG1 19H5 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, low APP reactive) antibody

Amyloid beta Mouse IgG1 19H11 Biotin Hu E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, low APP reactive) antibody

Amyloid beta Mouse IgG1 19H11 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-42 specific) antibody

Amyloid beta Mouse IgG1 12F4 Purified Hu E, P, WB
0.2 ml / €1,030.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, not APP reactive) antibody

Amyloid beta Mouse IgG1 7F4 Purified Hu E, ICC/IF, WB
0.1 mg / €630.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, not APP reactive) antibody

Amyloid beta Mouse IgG1 7F9 Purified Hu E, ICC/IF, WB
0.1 mg / €630.00
  Acris Antibodies GmbH

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