Ankyrin-1 antibody

Principal name

Ankyrin-1 antibody

Alternative names for Ankyrin-1 antibody

Erythrocyte ankyrin, Ankyrin-R, ANK1

SwissProt ID

P16157 (Human), Q02357 (Mouse)

Gene ID

286 (ANK1), 11733 (Ank1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Ankyrin-1 antibody

Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known.Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known. Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

General readings

Chang,T.L., (2004) Cell. Mol. Biol. (Noisy-le-grand) 50 (1), 59-66

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ankyrin-1 antibody

  Rabbit Polyclonal Anti-ANK1 Antibody  
WB Suggested Anti-ANK1 Antibody Titration: 1.25 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Ankyrin-1 antibody

  Rabbit Polyclonal Anti-ANK1 Antibody  
WB Suggested Anti-ANK1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ankyrin-1 (N-term) antibody

Ankyrin-1 Rabbit Purified Hu E, WB
1 ml / €390.00
  Acris Antibodies GmbH

Ankyrin-1 antibody

Ankyrin-1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Ankyrin-1 antibody

Western Blot analysis of ANK1 expression in transfected 293T cell line (H00000286-T01) by ANK1 MaxPab polyclonal antibody.

Lane 1: ANK1 transfected lysate(17.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Ankyrin-1 antibody

Ankyrin-1 Mouse IgG2a 3C3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Ankyrin-1 antibody

Hum. Fetal Liver; Host:Rabbit. Target Name:ANK1. Sample Tissue:Human Fetal Liver. Antibody Dilution: 1.0ug/ml.; ANK1 antibody - middle region (ARP41662_P050) in Hum. Fetal Liver cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Ankyrin-1 antibody

Human Skin; ANK1 antibody - C-terminal region (ARP42566_T100) in Human Skin cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Pan-Ankyrin antibody

Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Ankyrin-R knockout (KO) mouse brains probed with N388A/60 (left) and K58/35 (right) TC supe. Mouse brains courtesy of Matthew Rasband (Baylor College of Medicine). Mouse IgG1 N388A/60 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CRISPR

Catalog No. Species Donor Vector  

Ank1 - mouse gene knockout kit via CRISPR

Ank1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ank1 - mouse gene knockout kit via CRISPR

Ank1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ank1 - mouse gene knockout kit via CRISPR

Ank1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ank1 - mouse gene knockout kit via CRISPR

Ank1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Ankyrin-1

Ankyrin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Ankyrin-1

Ankyrin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

ANK1 (Human) IP-WB Antibody Pair

ANK1 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ANK1 (mGFP-tagged)-Human ankyrin 1, erythrocytic (ANK1), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, ANK1 (mGFP-tagged)-Human ankyrin 1, erythrocytic (ANK1), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, ANK1 (mGFP-tagged)-Human ankyrin 1, erythrocytic (ANK1), transcript variant 7, 200 uL, >10^7 TU/mL

Lenti ORF particles, ANK1 (mGFP-tagged)-Human ankyrin 1, erythrocytic (ANK1), transcript variant 7, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, ANK1 (mGFP-tagged)-Human ankyrin 1, erythrocytic (ANK1), transcript variant 10, 200 uL, >10^7 TU/mL

Lenti ORF particles, ANK1 (mGFP-tagged)-Human ankyrin 1, erythrocytic (ANK1), transcript variant 10, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, ANK1 (Myc-DDK tagged) - Human ankyrin 1, erythrocytic (ANK1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ANK1 (Myc-DDK tagged) - Human ankyrin 1, erythrocytic (ANK1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

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