Ankyrin-3 antibody

Principal name

Ankyrin-3 antibody

Alternative names for Ankyrin-3 antibody

ANK3, ANK-3, Ankyrin G

SwissProt ID

Q12955 (Human)

Gene ID

288 (ANK3), 1488778 (L270L)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), Mky (Monkey), Por (Porcine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Ankyrin-3 antibody

human: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq] mouse: This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ankyrin-3 antibody

Immunofluorescence (left) of axon initial segments with N106/43 (green), K39/25 (red) and K14/16 (blue). Mouse IgG1 N106/43 Supernatant Hu, Ms, Rt C, ICC/IF
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Ankyrin-3 antibody

Anti-ANK3 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. Goat Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

Ankyrin-3 antibody

Western blot analysis of Ankyrin-G in rat brain membrane tissues, using a 1:1000 dilution of the antibody Mouse IgG1 S106-20 Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Ankyrin-3 antibody

immunofluorescence staining of axon initial segments in adult rat cortex with N106/36 (red) and ßIV-spectrin rabbit polyclonal (green). Image courtesy of Matt Rasband (Baylor College of Medicine). Mouse IgG2a N106/36 Supernatant Hu, Ms, Rt C, ICC/IF
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Ankyrin-3 antibody

Adult rat brain immunohistochemistry Mouse IgG2b N106/65 Supernatant Hu, Ms, Rt C, ICC/IF
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Ankyrin-3 antibody

Adult rat brain membrane immunoblot Mouse IgG1 N106/20 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Ankyrin-3 antibody

immunofluorescence staining of axon initial segments in adult rat cortex with N106/36 (red) and ßIV-spectrin rabbit polyclonal (green). Image courtesy of Matt Rasband (Baylor College of Medicine). Mouse IgG2a N106/36 Purified Hu, Ms, Rt C, ICC/IF
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Ankyrin-3 antibody

Adult rat brain immunohistochemistry Mouse IgG2b N106/65 Purified Hu, Ms, Rt C, ICC/IF
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Ankyrin-3 antibody

Adult rat brain membrane immunoblot Mouse IgG1 N106/20 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Ankyrin-3 antibody

Ankyrin-3 Mouse IgG1 463 Purified Can, Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €1,170.00
  Acris Antibodies GmbH

10 Item(s)

per page
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