Annexin A2 / ANXA2 antibody

Principal name

Annexin A2 / ANXA2 antibody

Alternative names for Annexin A2 / ANXA2 antibody

ANX2, ANX2L4, CAL1H, LPC2D, Annexin-2, Annexin II, Lipocortin II, Calpactin I heavy chain, Chromobindin-8, p36, Protein I, Placental anticoagulant protein IV

SwissProt ID

P04272 (Bovin), P07355 (Human), P07356 (Mouse), P17785 (Chick), Q07936 (Rat)

Gene ID

302 (ANXA2)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Can (Canine), Chk (Chicken), Sh (Sheep), Mky (Monkey), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Goat, Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of Annexin A2 / ANXA2 antibody

Annexin A2 (ANXA2), also known as lipocortin II or calpactin-1 heavy chain, is a 36 kDa member of the annexin superfamily that binds phospholipids and other proteins in a calcium-dependent manner via annexin repeats. Annexin A2 contains four such repeats through which it mediates protein-protein and protein-lipid interactions. It forms a constitutive heterotetramer with S100A10, acting as a bridge between the actin cytoskeleton, plasma membrane, and endocytotic vesicle machinery. Origilly identified as a protein inhibitor of phospholipase A2, annexin A2 has subsequently been shown to interact with an array of protein and non-protein partners, including F-actin, spectrin, SRE complexes, R, and virus particles. Annexin A2 has also been shown to have receptor-like activity and is detected on the surface of macrophages and vascular endothelial cells where it mediates macrophage activation and Factor Xa sigling, respectively . Upregulation of annexin A2 at the cell surface is thought to be modulated by phosphorylation at Tyr23 by Src. Interestingly, phosphorylation at Tyr23 has recently been shown to be required for cell surface expression of annexin A2 where it mediates motility, invasiveness, and overall metastatic potential of certain pancreatic cancer cells. Annexin A2 has also been shown to be heavily phosphorylated on serine residues in response to PKC activation via a pleiotropic mechanism. For a complete list of curated phosphorylation sites on annexin A2, please see PhosphoSitePlus® at www.phosphosite.org.

General readings

Takahashi S et al. Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. J Biol Chem 269:28696-701 (1994). PubMed PMID: 7961821

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Annexin A2 / ANXA2 antibody

Immunohistochemistry: Annexin A2 Antibody [NBP1-31310] - Immunohistochemical analysis of paraffin-embedded Human pancreas tissue, using Annexin A2 antibody at 1:100 dilution. Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Annexin A2 / ANXA2 (N-term) antibody

Antibody staining (1µg/ml) of A431 lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Por, Rt WB
20 µg / €200.00
  Acris Antibodies GmbH

Annexin A2 / ANXA2 (N-term) antibody

Antibody staining (1µg/ml) of A431 lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Annexin A2 / ANXA2 antibody

Western blot analysis of HeLa cell lysates with anti-Annexin A2 antibody (1:200). Rabbit Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Annexin A2 / ANXA2 antibody

Predicted band size: 38kDa. Positive control: HepG2 cell lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lysates: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 15 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Annexin A2 / ANXA2 antibody

Predicted band size: 38kDa. Positive control: 293T and HepG2 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: 293T cell lysate Lane2: HepG2 cell lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Annexin A2 / ANXA2 antibody

Western blot analysis of extracts of A2058 cell lines, using ANXA2 antibody. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Annexin A2 / ANXA2 antibody

WB Suggested Anti-ANXA2 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Sh WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Annexin A2 / ANXA2 (N-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ANXA2 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Annexin A2 / ANXA2 (C-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ANXA2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Annexin A2 / ANXA2 antibody

Immunohistochemistry (IHC) analyzes of Annexin II antibody (Cat.-No.: AP20666PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Annexin A2 / ANXA2 (N-term) antibody

Human Lung, Respiratory Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Annexin A2 / ANXA2 pSer26 antibody

Western blot analysis of extracts from HepG2 cells JK cells and K562 cells using ANXA2 (Phospho-Ser26) Antibody AP55852PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Annexin A2 / ANXA2 pSer26 antibody

Western blot analysis of extracts from HepG2 cells JK cells and K562 cells using ANXA2 (Phospho-Ser26) Antibody AP55852PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

Annexin A2 / ANXA2 antibody

ANXA2 polyclonal antibody (A01), Lot # Abnova060427QCS1. Western Blot analysis of ANXA2 expression in NIH/3T3. Mouse Serum Hu, Ms, Rt E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Annexin A2 / ANXA2 antibody

Immunofluorescence of purified MaxPab antibody to ANXA2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

Annexin A2 / ANXA2 antibody

ANXA2 MaxPab rabbit polyclonal antibody. Western Blot analysis of ANXA2 expression in mouse lung. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Annexin A2 / ANXA2 antibody

Immunofluorescence of monoclonal antibody to ANXA2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 3E8-B6 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Annexin A2 / ANXA2 antibody

Immunofluorescence of monoclonal antibody to ANXA2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 1G7 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Annexin A2 / ANXA2 antibody

ANXA2 monoclonal antibody (M08), clone 4G8. Western Blot analysis of ANXA2 expression in A-431(Cat # L015V1 ). Mouse IgG2a 4G8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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