Anoctamin-2 antibody

Principal name

Anoctamin-2 antibody

Alternative names for Anoctamin-2 antibody

ANO2, C12orf3, TMEM16B, Transmembrane protein 16B

SwissProt ID

Q8CFW1 (Mouse), Q9NQ90 (Human)

Gene ID

57101 (ANO2), 243634 (Ano2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts


Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of Anoctamin-2 antibody

Anoctamin (ANO, or TMEM16) is a family of membrane proteins which includes 10 members. This family is med so because these channels selective to ANions and have eight (OCT) transmembrane domains. Also, these channels are subject to glycosylation in their extracellular loops and have both intracellular N- and C-termini. Members of this family are expressed in a broad range of different organisms ranging from mammals, flies, worms, plants as well as yeast. Altertive splicing is known to affect these channels and regarding their oligomerization state, homedimerization has been observed although when heterologously expressed, these channels may hetero oligomerize. Ano1 (or TMEM16A, DOG1 and others) the first member to be identified was found to be a Ca2+-activated Cl channel therefore other members are likely to also be Cl channels. These channels are expressed in many different tissues: bronchiolar epithelial cells, pancreatic acir cells, proximal kidney tubule epithelium, reti, dorsal root ganglia and submandibular gland. In fact, Ano1 gained a lot of attention as its activation may serve as a therapeutic treatment for cystic fibrosis since it is also expressed in the airways. These Ca2+-activated Cl channels are believed to play a role in development as knock out of Ano1 in mice causes abnormal development of the trachea. Ano2 (TMEM16B) has been shown to mediate Ca2+-activated Cl current in olfactory epithelium and photoreceptor sypses. Although relatively newly discovered channels, they are being discovered in many medical indications. Ano1 has become a marker in gastrointestil tumors as its expression is significantly upregulated in such tumors. Similarly, Ano1 is also highly expressed other carcinomas.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Anoctamin-2 antibody

Anoctamin-2 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
  OriGene Technologies, Inc.

Anoctamin-2 (N-term) antibody

Anoctamin-2 Rabbit Hu, Ms, Rt E, P, WB
  OriGene Technologies, Inc.

Anoctamin-2 antibody

Anoctamin-2 Rabbit Purified Ms, Rt WB
  OriGene Technologies, Inc.

Anoctamin-2 Control Peptide

  Acris Antibodies GmbH

Anoctamin-2 antibody

Anoctamin-2 Rabbit Aff - Purified Hu ICC/IF, P, WB
  Novus Biologicals Inc.

5 Item(s)

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