Antileukoproteinase / ALP antibody

Principal name

Antileukoproteinase / ALP antibody

Alternative names for Antileukoproteinase / ALP antibody

SLPI, WAP4, WFDC4, Secretory leukocyte protease inhibitor, HUSI-1, Seminal proteinase inhibitor, BLPI, Mucus proteinase inhibitor, WAP four-disulfide core domain protein 4, Protease inhibitor WAP4

SwissProt ID

P03973 (Human), P22298 (Pig), P97430 (Mouse)

Gene ID

6590 (SLPI), 20568 (Slpi)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Neutralisation (NEUT), ELISA (detection) (E(detection))

Background of Antileukoproteinase / ALP antibody

SLPI was identified as an alarm reactant and expression is induced by inflammatory factors like LPS, IL1β, TNFα and neutrophils elastase. SLPI is a relatively small basic antiprotease of 11.7 kDa and is a cationic non-glycosylated protein consisting of 107amino acids. SLPI has a high affinity for the neutrophil serine proteinases, elastase and cathepsin G. Orthologues of SLPI have been found in mice, rate, pigs and sheep. It consists of two highly similar WAP (‘whey acid protein’)/four-disulphide core domains. SLPI contain 16 cysteine residues which assemble into eight disulphide bridges (four in each WAP domain). SLPI is constitutively expressed at many mucosal surfaces and is produced by a variety of epithelial cells, including respiratory, intestinal and amniotic epithelia. Expression is also detected in mast cells, neutrophils and macrophages. Expression of SLPI gene is significantly increased by progesterone and by the pro-inflammatory cytokines TNF-α and IL1-β. Although SLPI has been shown to inhibit a spectrum of proteases (including HNE, cathepsin G, trypsin, chymotrypsin and chymase), its main action in this regard is likely to be the inhibition of elastase, as indicated by its low dissociation constant and favourable kinetics of inhibition for this enzyme. SLPI has been described in several body fluids like seminal fluid, bronchial fluids, cervical fluids and saliva. It has been found to be antibacterial, antifungal, anti-retroviral, and to have an important role in mucosal defence. SLPI might also facilitate tumor spread, contributing to wound healing, is elevated in sepsis and levels seem to correlate with oral candidiasis in HIV-1 positive patients.

General readings

De Water, R et al; Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies. Am Rev Resp Dis 1986, 133: 882

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Antileukoproteinase / ALP antibody

Western blot analysis of SLPI in Daudi cell lysate with SLPI antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Antileukoproteinase / ALP antibody

Western blot analysis of SLPI in A-20 cell lysate with SLPI antibody at 2 µg/ml. Rabbit IgG Aff - Purified Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Antileukoproteinase / ALP antibody

Anti-SLPI antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. Goat IgG Aff - Purified Hu E, NEUT, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

Antileukoproteinase / ALP antibody

Specimen was fixed in 4% formalin for 4h. Paraffin sections (4µm) were deparifinized, rehydrated and blocked with normal serum. Optional antigen retrieval with citrate buffer. Section was incubated with 5µg/ml mAb Mouse IgG1 31 Biotin Hu C, E, P, WB
50 µg / €390.00
  Acris Antibodies GmbH

Antileukoproteinase / ALP antibody

Specimen was fixed in 4% formalin for 4h. Paraffin sections (4µm) were deparifinized, rehydrated and blocked with normal serum. Optional antigen retrieval with citrate buffer. Section was incubated with 5µg/ml mAb Mouse IgG1 31 Purified Hu C, E, IP, P, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

Antileukoproteinase / ALP antibody

Formalin fixed, paraffin embedded mouse lung stained with Rabbit anti Human SLP1 (AP05707PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0) Rabbit IgG Purified Hu, Ms P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Antileukoproteinase / ALP antibody

Antileukoproteinase / ALP Rabbit IgG Purified Hu E, IP, WB
0.1 mg / €520.00
  Acris Antibodies GmbH

Antileukoproteinase / ALP Control Peptide

Antileukoproteinase / ALP
50 µg / €160.00
  Acris Antibodies GmbH

Antileukoproteinase / ALP Control Peptide

Antileukoproteinase / ALP
50 µg / €160.00
  Acris Antibodies GmbH

Antileukoproteinase / ALP antibody

Antileukoproteinase / ALP Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Antileukoproteinase / ALP antibody

Antileukoproteinase / ALP Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Antileukoproteinase / ALP antibody

Antileukoproteinase / ALP Mouse IgG2a 3C6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Antileukoproteinase / ALP antibody

Immunohistochemistry of SLPI in mouse lung tissue with SLPI polyclonal antibody ( Cat # PAB13274 ) at 10 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Antileukoproteinase / ALP antibody

Western blot analysis of Slpi in A-20 cell lysate with Slpi polyclonal antibody ( Cat # PAB13275 ) at 2 µg/ml. Rabbit Ms WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Antileukoproteinase / ALP (N-term) antibody

Antileukoproteinase / ALP Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Antileukoproteinase / ALP antibody

Antileukoproteinase / ALP Goat IgG Hu E, NEUT, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

Antileukoproteinase / ALP antibody

Antileukoproteinase / ALP Mouse IgG1 31 Hu, Rt C, E, IP, P, WB
50 µg / €620.00
  Novus Biologicals Inc.

Antileukoproteinase / ALP antibody

Antileukoproteinase / ALP Mouse IgG1 31 Purified Hu C, E, P, WB
25 µg / €340.00
  Novus Biologicals Inc.

Antileukoproteinase / ALP antibody

Immunohistochemistry-Paraffin: SLPI Antibody [NBP1-76803] - Mouse lung tissue with SLPI antibody at 10 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Antileukoproteinase / ALP

Antileukoproteinase / ALP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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