AOC3 / VAP1 antibody

Principal name

AOC3 / VAP1 antibody

Alternative names for AOC3 / VAP1 antibody

HPAO, Membrane primary amine oxidase, Copper amine oxidase, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1

SwissProt ID

O08590 (Rat), O70423 (Mouse), Q16853 (Human), Q9TTK6 (Bovin)

Gene ID

8639 (AOC3), 11754 (Aoc3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Mouse, Rabbit, Rat

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of AOC3 / VAP1 antibody

The monoclonal antibody 7-88 recognizes mouse Vascular Adhesion Protein-1 (VAP-1) which is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is expressed in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end-products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. In white adipose tissue of obese and diabetic db-/- mice increased expression of VAP-1 has been observed suggesting that it contributes to the arthrosclerosis and vascular dysfunction observed in these diseases. Moreover, inhibition of VAP-1reduced the accumulation of myeloid cells into tumors and attenuates tumor growth. The monoclonal antibody 7-88 inhibits migration of granulocytes and monocytes in acute models of inflammation.

General readings

Forster-Horvath C, Dome B, Paku S, Ladanyi A, Somlai B, Jalkanen S, Timar J.
Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma.
Melanoma Res. 2004 Apr;14(2):135-40.
PMID: 15057044.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AOC3 / VAP1 antibody

Staining of A549 lysate using AOC3 / VAP1 Antibody Cat.-No AP32053PU-N at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

AOC3 / VAP1 antibody

TA305833 (3.8ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

AOC3 / VAP1 (Center) antibody

Western blot analysis of AOC3 Antibody (Center) (Cat. #TA325044) in CEM cell line lysates (35ug/lane).AOC3 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

AOC3 / VAP1 antibody

Western blot analysis of extracts of various cell lines, using AOC3 antibody. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AOC3 / VAP1 antibody

Immunohistochemical analysis of VAP-1 on human tonsil tissue. Staining of frozen  tissue section with antibody 174-5 (AM26204PU-N). Anti-human VAP-1 staining results in vessels that are VAP-1 positive, whereas morphologically similar vessels next to positive ones can be negative. Mouse IgG1 174-5 Purified Hu, Rt C, FN, ICC/IF
0.1 mg / €490.00
  Acris Antibodies GmbH

AOC3 / VAP1 antibody

Frozen Sections: VAP-1 expression in mouse muscle tissue. Rat IgG2b 7-88 Purified Ms C, FN, ICC/IF, IP
0.1 mg / €490.00
  Acris Antibodies GmbH

AOC3 / VAP1 (712-724) antibody

Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bov, Elephant, Hst, Hu, Mky, Ms, Prim, Rb, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

AOC3 / VAP1 antibody

AOC3 / VAP1 Mouse Purified Hu E(detection), P, WB
50 µg / €370.00
  Abnova Taiwan Corp.

AOC3 / VAP1 antibody

AOC3 / VAP1 Mouse IgG2a 4B8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

AOC3 / VAP1 antibody

AOC3 / VAP1 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

AOC3 / VAP1 antibody

Immunohistochemistry: AOC3 Antibody[100-57090]-(3.8ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €400.00
  Novus Biologicals Inc.

AOC3 / VAP1 antibody

Western Blot:VAP1 Antibody [NBP1-31935]- (30 ug of whole cell lysate) A: A431  7.5% SDS PAGE VAP1 antibody  diluted at 1:1000 Rabbit IgG Hu P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

AOC3 / VAP1 antibody

Immunohistochemistry-Paraffin: VAP1 Antibody (7-88) [NBP1-58374] - VAP-1 expression in mouse muscle tissue; frozen sections. Rat IgG2b 7-88 Purified Ms C, F, FN, ICC/IF, IP
25 µg / €360.00
  Novus Biologicals Inc.

AOC3 / VAP1 antibody

AOC3 / VAP1 Mouse IgG1 174-5 Purified Hu, Rt C, F, ICC/IF, P
25 µg / €360.00
  Novus Biologicals Inc.

AOC3 / VAP1 antibody

Immunohistochemistry-Paraffin: VAP1 Antibody [NBP1-89671] Immunohistochemical staining of human rectum shows distinct positivity in endothelial cells and smooth muscle. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AOC3 / VAP1

AOC3 / VAP1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
CHO cells

Regular Price: 10 µg / €399.00

Special Price: 10 µg / €239.00

  OriGene Technologies, Inc.

AOC3 / VAP1

AOC3 / VAP1 Human Purified > 95 % by SDS-PAGE and HPLC analyses CHO cells
10 µg / €220.00
  Acris Antibodies GmbH

AOC3 / VAP1

AOC3 / VAP1 Human Purified > 95 % by SDS-PAGE and HPLC analyses CHO cells
2 µg / €140.00
  Acris Antibodies GmbH

AOC3 / VAP1

AOC3 / VAP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
2 µg / €300.00
  Abnova Taiwan Corp.

AOC3 / VAP1

AOC3 / VAP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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