AOC3 / VAP1 antibody

Principal name

AOC3 / VAP1 antibody

Alternative names for AOC3 / VAP1 antibody

HPAO, Membrane primary amine oxidase, Copper amine oxidase, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1

SwissProt ID

O08590 (Rat), O70423 (Mouse), Q16853 (Human), Q9TTK6 (Bovin)

Gene ID

8639 (AOC3), 11754 (Aoc3), 29473

Available reactivities

Hu (Human), Bov (Bovine), Hst (Hamster), Mky (Monkey), Ms (Mouse), Prim (Primate), Rb (Rabbit), Rt (Rat)

Available hosts

Goat, Mouse, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Frozen Sections (C), Immunoprecipitation (IP)

Background of AOC3 / VAP1 antibody

Vascular Adhesion Protein-1 (VAP-1) is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia.
VAP-1 is present in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end-products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. Elevated sVAP-1serum levels have been described in several inflammatory diseases as well as colorectal cancer. Moreover, diminished insulin secretion appears to increase the concentration of soluble VAP-1 in plasma. Therefore, VAP-1 might be an interesting diagnostic marker as well therapeutic target for modulating inflammation.

General readings

Forster-Horvath C, Dome B, Paku S, Ladanyi A, Somlai B, Jalkanen S, Timar J.
Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma.
Melanoma Res. 2004 Apr;14(2):135-40.
PMID: 15057044.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AOC3 / VAP1 antibody

Staining of A549 lysate using AOC3 / VAP1 Antibody Cat.-No AP32053PU-N at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

AOC3 / VAP1 antibody

  Goat Anti-AOC3 Antibody  
TA305833 (3.8ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

AOC3 / VAP1 (Center) antibody

  Rabbit polyclonal AOC3 Antibody (Center)  
Western blot analysis of AOC3 Antibody (Center) (Cat. #TA325044) in CEM cell line lysates (35ug/lane).AOC3 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

AOC3 / VAP1 antibody

  Rabbit anti-AOC3 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using AOC3 antibody. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AOC3 / VAP1 antibody

Immunohistochemical analysis of VAP-1 on human tonsil tissue. Staining of frozen  tissue section with antibody 174-5 (AM26204PU-N). Anti-human VAP-1 staining results in vessels that are VAP-1 positive, whereas morphologically similar vessels next to positive ones can be negative. Mouse IgG1 174-5 Purified Hu, Rt C, FN, ICC/IF
0.1 mg / €500.00
  Acris Antibodies GmbH

AOC3 / VAP1 antibody

Frozen Sections: VAP-1 expression in mouse muscle tissue. Rat IgG2b 7-88 Purified Ms C, FN, ICC/IF, IP
0.1 mg / €500.00
  Acris Antibodies GmbH

AOC3 / VAP1 (712-724) antibody

Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bov, Elephant, Hst, Hu, Mky, Ms, Prim, Rb, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

AOC3 - human gene knockout kit via CRISPR

AOC3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AOC3 - human gene knockout kit via CRISPR

AOC3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AOC3 - human gene knockout kit via CRISPR

AOC3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AOC3 - human gene knockout kit via CRISPR

AOC3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aoc3 - mouse gene knockout kit via CRISPR

Aoc3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Aoc3 - mouse gene knockout kit via CRISPR

Aoc3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aoc3 - mouse gene knockout kit via CRISPR

Aoc3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aoc3 - mouse gene knockout kit via CRISPR

Aoc3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AOC3 / VAP1

  Purified recombinant protein of Human amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3).  
AOC3 / VAP1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
CHO cells

Regular Price: 10 µg / €399.00

Special Price: 10 µg / €239.00

  OriGene Technologies, Inc.

AOC3 / VAP1

AOC3 / VAP1 Human Purified > 95 % by SDS-PAGE and HPLC analyses CHO cells
10 µg / €220.00
  Acris Antibodies GmbH

AOC3 / VAP1

AOC3 / VAP1 Human Purified > 95 % by SDS-PAGE and HPLC analyses CHO cells
2 µg / €140.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AOC3 (mGFP-tagged) - Human amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3), 200 uL, >10^7 TU/mL

Lenti ORF particles, AOC3 (mGFP-tagged) - Human amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, AOC3 (Myc-DDK tagged) - Human amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3) , 200 uL, >10^7 TU/mL

Lenti ORF particles, AOC3 (Myc-DDK tagged) - Human amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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