AP2A2 / HIP9 antibody

Principal name

AP2A2 / HIP9 antibody

Alternative names for AP2A2 / HIP9 antibody

AP-2 complex subunit alpha-2, Alpha-2-adaptin, Alpha-adaptin C, ADTAB, CLAPA2, HYPJ, KIAA0899, Huntingtin-interacting protein 9, Adapter-related protein complex 2 alpha-2 subunit, Adaptor protein complex AP-2 subunit alpha-2, Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit,lathrin assembly protein complex 2 alpha-C large chain, 100 kDa coated vesicle protein C, Huntingtin-interacting protein J, Huntingtin yeast partner J

SwissProt ID

O94973 (Human)

Gene ID

161 (AP2A2)

Available reactivities

Can (Canine), Chimp (Chimpanzee), Chk (Chicken), Hu (Human), Ms (Mouse), Orang-Utan, Rt (Rat), GP (Guinea Pig), Por (Porcine)

Available hosts

Goat, Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C), Paraffin Sections (P)

Background of AP2A2 / HIP9 antibody

AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AP2A2 / HIP9 (3-14) antibody

WB using Anti-AP2A antibody shows detection of a band just below 100 kDa correspond-ing to Human AP2A1 in a various preparations. Lane 1 - HeLa nuclear extract, Lane 2 - HeLa, Lane 3 - 293, Lane 4 - A431 and Lane 5 - Jurkat whole cell lysates. In lanes 6-10 the antibody was preincubated with 1 µg/ml of the immunizing peptide which effect-ively blocks the specific reactivity of this antibody with AP2A. Primary antibody was used at 1:500. Goat IgG Aff - Purified Can, Chimp, Chk, Hu, Ms, Orang-Utan, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AP2A2 / HIP9 (Center) antibody

Western blot analysis of AP2A2 Antibody (Center) (Cat. #TA325045) in HepG2 cell line lysates (35ug/lane). AP2A2 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

AP2A2 / HIP9 antibody

Western blot analysis of extracts of various cell lines, using AP2A2 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AP2A2 / HIP9 antibody

WB Suggested Anti-AP2A2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Lung Rabbit IgG Purified Can, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

AP2A2 / HIP9 Control Peptide

AP2A2 / HIP9
50 µg / €190.00
  Acris Antibodies GmbH

AP2A2 / HIP9 (C-term) antibody

AP2A2 / HIP9 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

AP2A2 / HIP9 antibody

AP2A2 / HIP9 Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

AP2A2 overexpression lysate

AP2A2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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