APAF1 antibody

Principal name

APAF1 antibody

Alternative names for APAF1 antibody

Apaf-1, KIAA0413, Apoptotic protease-activating factor 1

SwissProt ID

O14727 (Human), O88879 (Mouse), Q9EPV5 (Rat), Q9GL23 (Canfa)

Gene ID

317 (APAF1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C)

Background of APAF1 antibody

Apoptotic peptidase activating factor 1, also known as APAF1, is a protein which in humans is encoded by the APAF1 gene. This gene is mapped to chromosome 12q23.1 It encodes a cytoplasmic protein that initiates apoptosis. And it is an essential downstream effector of p53-mediated apoptosis.2 This protein contains several copies of the WD40 repeat domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). In the presence of cytochrome c and dATP, APAF1 assembles into an oligomeric apoptosome, which is responsible for activation of procaspase-9 and maintenance of the enzymatic activity of processed caspase-9.3 Furthermore, APAF1 is inactivated in metastatic melanomas, leading to defects in the execution of apoptotic cell death.4 Additionally, APAF1 has been shown to interact with NLRP1,5 Caspase-9,5, 6, 7, 8, 9, 10 APIP,6 BCL2-like 18, 9 and HSPA4.10

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APAF1 (C-term) antibody

Human Spleen (formalin-fixed, paraffin-embedded) stained with APAF1 antibody AP22708PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

APAF1 (N-term) antibody

  Rabbit Polyclonal Apaf1 Antibody  
Western blot analysis of Apaf1 in K562 cell lysate with Apaf1 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APAF1 (C-term) antibody

  Rabbit Polyclonal Apaf1 Antibody  
Western blot analysis of Apaf1 in human heart tissue lysate with Apaf1 antibody at 1 ug/ml dilution in the absence (A) or presence (B) of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Rabbit polyclonal APAF-1-ALT antibody  
Western blot analysis of extracts from COLO205, using APAF-1-ALT antibody (#TA313453).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Mouse Apaf-1 Monoclonal Antibody  
Western blot analysis of Apaf1 in K562 cell lysate with Apaf1 antibody at (A) 0.25 and (B) 0.5 mg/mL. Mouse 2E10 Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Mouse Apaf-1 Monoclonal Antibody  
Immunohistochemistry of Apaf1 in K562 cells with Apaf1 antibody at 0.5 ug/mL. Mouse IgG 5E11 Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Anti-APAF1 Rabbit Polyclonal Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using APAF1 Antibody at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Anti-APAF1 Rabbit Polyclonal Antibody  
Gel: 6%SDS-PAGE,Lysate: 40 µg,Lane 1-3: Hela cells, A549 cells, HUVEC cells,Primary antibody: APAF1 Antibody at dilution 1/350 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Anti-APAF1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human brain and cervical cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human brain and cervical cancer tissue using APAF1 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Anti-APAF1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human cervical and ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical and ovarian cancer tissue using APAF1 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

APAF1 antibody

  Rabbit Polyclonal Anti-APAF1 Antibody  
Western blot analysis on COLO205 cell lysate using APAF1 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APAF1 (1-421) antibody

APAF1 Mouse IgG1 5C1 Azide Free Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

APAF1 antibody

Western blot analysis using anti-Apaf1 antibody at 1 µg/ml on human heart tissue lysate in the absense (A) and presense (B) of blocking peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €440.00
  Acris Antibodies GmbH

APAF1 antibody

APAF1 Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €440.00
  Acris Antibodies GmbH

APAF1 antibody

Immunohistochemical staining of human heart with Rabbit anti APAF1 antibody Cat.-No AP05812PU-N Rabbit IgG Purified Hu, Ms P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

APAF1 antibody

Immunohistochemical staining of human heart with Rabbit anti APAF1 antibody Cat.-No AP05812PU-N Rabbit IgG Purified Hu, Ms P, WB
50 µg / €280.00
  Acris Antibodies GmbH

APAF1 antibody

Immunohistochemical analysis ussing APAF1 antibody (Cat.-No. AP06014PU-N) in Paraffin-embedded human lung carcinoma tissue.
	. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

APAF1 antibody

Figure 2. Staining APAF1 in Heart by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

APAF1 (N-term) antibody

Immunohistochemistry with APAF1 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

APAF1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using APAF-1-ALT Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P, WB
50 µg / €230.00
  Assay Biotech

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