APBA3 / MINT3 antibody

Principal name

APBA3 / MINT3 antibody

Alternative names for APBA3 / MINT3 antibody

Neuron-specific X11L2 protein, Adapter protein X11gamma, Amyloid beta A4 precursor protein-binding family A member 3, Neuronal Munc18-1-interacting protein 3

SwissProt ID

O70248 (Rat), O88888 (Mouse), O96018 (Human)

Gene ID

83611 (Apba3), 9546 (APBA3)

Available reactivities

Ms (Mouse), Rt (Rat), Can (Canine), Hu (Human)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of APBA3 / MINT3 antibody

The munc-18 interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that mint3 does not interact with munc-18. Mint3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.

General readings

General / background references:Nakajima Y et al. Neuronal expression of mint1 and mint2, novel multimodular proteins, in adult murine brain. Brain Res Mol Brain Res 92:27-42 (2001). PubMed PMID: 11483239
Okamoto M et al. Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane. Neuroscience 104:653-65 (2001). PubMed PMID: 11440799
Tanahashi H & Tabira T X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein. Biochem Biophys Res Commun 255:663-7 (1999). PubMed PMID: 10049767

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APBA3 / MINT3 antibody

WB Suggested Anti-APBA3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

APBA3 / MINT3 antibody

Western blot analysis of extracts from HuvEc cells, using APBA3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

APBA3 / MINT3 antibody

Western blot analysis of extracts from HuvEc cells, using APBA3 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

APBA3 / MINT3 antibody

Human HepG2; WB Suggested Anti-APBA3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; APBA3 antibody - N-terminal region (AVARP13005_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Can, Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

APBA3 / MINT3 antibody

Western Blot: Mint 3 Antibody [NB120-3450] - Figure 1 illustrates Western blot detection of Mint3 from AtT20 cell extract using NB120-3450. Rabbit IgG Aff - Purified Ms, Rt WB
0.1 mg / €400.00
  Novus Biologicals Inc.

APBA3 / MINT3 antibody

APBA3 / MINT3 Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

APBA3 / MINT3 antibody

APBA3 / MINT3 Rabbit IgG Aff - Purified Hu E, WB
50 µg / €290.00
  Novus Biologicals Inc.

APBA3 / MINT3 antibody

Immunohistochemistry-Paraffin: Mint 3 Antibody [NBP1-92117] - Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

APBA3 / MINT3

APBA3 / MINT3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

APBA3 / MINT3

APBA3 / MINT3 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

APBA3 overexpression lysate

APBA3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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