APBB1 / FE65 antibody

Principal name

APBB1 / FE65 antibody

Alternative names for APBB1 / FE65 antibody

RIR, Amyloid beta A4 precursor protein-binding family B member 1

SwissProt ID

O00213 (Human), P46933 (Rat), Q9QXJ1 (Mouse)

Gene ID

322 (APBB1), 29722 (Apbb1), 11785

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of APBB1 / FE65 antibody

Apbb1 is an adapter protein that forms a transcriptiolly active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domaipbb1 plays a central role in the response to D damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Apbb1 is required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity.Apbb1 functions in association with TSHZ3, SET and HDAC factors as a transcriptiol repressor, that inhibits the expression of CASP4. Apbb1 is associates with chromatin in a region surrounding the CASP4 transcriptiol start site(s).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APBB1 / FE65 antibody

  Rabbit anti-APBB1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using APBB1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

APBB1 / FE65 antibody

  Rabbit Polyclonal Antibody against Fe65  
Detection of FE65 protein in HEK 293 cell lysate Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APBB1 / FE65 antibody

  Goat Polyclonal Antibody against APBB1 / FE65  
TA302412 (0.1µg/ml) staining of NIH/3T3 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APBB1 / FE65 antibody

  Rabbit polyclonal Anti-Apbb1 Antibody  
WB Suggested Anti-Apbb1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Mouse Heart Rabbit IgG Purified Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

APBB1 / FE65 antibody

Western blot analysis using FE65 and HEK 293 cell lysates Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 ml / €380.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

APBB1 - human gene knockout kit via CRISPR

APBB1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

APBB1 - human gene knockout kit via CRISPR

APBB1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Apbb1 - mouse gene knockout kit via CRISPR

Apbb1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Apbb1 - mouse gene knockout kit via CRISPR

Apbb1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Apbb1 - mouse gene knockout kit via CRISPR

Apbb1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Apbb1 - mouse gene knockout kit via CRISPR

Apbb1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

APBB1 / FE65 (transcript variant 1)

  Recombinant protein of human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1  
APBB1 / FE65 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

APBB1 / FE65 (transcript variant 2)

  Recombinant protein of human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 2  
APBB1 / FE65 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

APBB1 overexpression lysate

APBB1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

APBB1 overexpression lysate

APBB1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, APBB1 (mGFP-tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, APBB1 (mGFP-tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, APBB1 (mGFP-tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, APBB1 (mGFP-tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, APBB1 (Myc-DDK tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, APBB1 (Myc-DDK tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, APBB1 (Myc-DDK tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, APBB1 (Myc-DDK tagged) - Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Apbb1 (GFP-tagged) - Mouse amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Apbb1 (GFP-tagged) - Mouse amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1), 200 uL, >10^7 TU/mL  
200 µl / €1,390.00
  OriGene Technologies, Inc.

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