APC / DP2.5 antibody

Principal name

APC / DP2.5 antibody

Alternative names for APC / DP2.5 antibody

Adenomatous polyposis coli protein, Deleted in polyposis 2.5

SwissProt ID

P25054 (Human), P70478 (Rat), Q61315 (Mouse)

Gene ID

324 (APC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Por (Porcine), Bov (Bovine), Chk (Chicken)

Available hosts

Rabbit, Mouse, Rat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of APC / DP2.5 antibody

The adenomatous polyposis syndromes, familial adenomatous polyposis(FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length with a molecular weight of 300 kDa, which is frequently mutated in patients suffering from FAP and GS. APC has recently been found to be associated with structural components of intracellular junctions. beta-catenin and gamma-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both beta- and gamma-catenin. Interactions between the cytoskeleton and the APC, E cadherin and beta/gamma catenin complex are mediated by alpha-catenin. Like APC, APC2 contains SAMP domains, which are required for conductin binding. Both APC and APC2 regulate the formation of active beta-catenin-Tcf complexes.

General readings

General / background references:Bhat RV et al. Expression of the APC tumor suppressor protein in oligodendroglia. Glia 17:169-74 (1996). PubMed PMID: 8776583
Bhat RV et al. High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system. J Neurosci 14:3059-71 (1994). PubMed PMID: 8182459
Smith KJ et al. Wild-type but not mutant APC associates with the microtubule cytoskeleton. Cancer Res 54:3672-5 (1994). PubMed PMID: 8033082
Smith KJ et al. The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A 90:2846-50 (1993). PubMed PMID: 8385345
Su LK et al. Association between wild type and mutant APC gene products. Cancer Res 53:2728-31 (1993). PubMed PMID: 8389242
Su LK et al. Association of the APC tumor suppressor protein with catenins. Science 262:1734-7 (1993). PubMed PMID: 8259519
Groden J et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66:589-600 (1991). PubMed PMID: 1651174
Kinzler KW et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 251:1366-70 (1991). PubMed PMID: 1848370

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APC / DP2.5 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-APC mouse monoclonal antibody. (TA803655; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG1 OTI2B8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

APC / DP2.5 antibody

Human colon carcinoma stained with Anti-APC antibody Rabbit Purified Hu, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Human colon carcinoma stained with Anti-APC antibody Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €440.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Human colon carcinoma stained with Anti-APC antibody Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using APC antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

APC / DP2.5 antibody

Western blot analysis of extracts from J COLO205tcells, using APC antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APC / DP2.5 antibody

Western blot analysis on HuvEc cell lysate using APC Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APC / DP2.5 antibody

ELISA: APC Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

APC / DP2.5 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-APC mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803682) Mouse IgG1 OTI1B12 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

APC / DP2.5 antibody

Figure 1. Mouse APC Rat IgG2a KT44 Aff - Purified Ms E, ICC/IF, WB
1 mg / €910.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Figure 1. Mouse APC Rat IgG2a KT44 Aff - Purified Ms E, ICC/IF, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Figure 1. Mouse APC Rat IgG2a KT44 Aff - Purified Ms E, ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Figure 1. Mouse APC Rat IgG2a KT45 Aff - Purified Ms E, ICC/IF, WB
1 mg / €910.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Figure 1. Mouse APC Rat IgG2a KT45 Aff - Purified Ms E, ICC/IF, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Figure 1. Mouse APC Rat IgG2a KT45 Aff - Purified Ms E, ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Immunohistochemical analysis in paraffin-embedded human lung carcinoma tissue using APC / DP2.5 antibody (Cat.-No. AP06015PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

Immunohistochemistry (IHC) analyzes of APC antibody (Cat.-No.: AP06494PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

APC / DP2.5 (C-term) antibody

Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.25 ml / €470.00
  Acris Antibodies GmbH

APC / DP2.5 antibody

APC / DP2.5 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

APC / DP2.5 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between APC and CTNNB1. HeLa cells were stained with anti-APC rabbit purified polyclonal 1:1200 and anti-CTNNB1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

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