APG16L / ATG16L1 antibody

Principal name

APG16L / ATG16L1 antibody

Alternative names for APG16L / ATG16L1 antibody

Autophagy-related protein 16-1, APG16-like 1

SwissProt ID

Q676U5 (Human), Q8C0J2 (Mouse)

Gene ID

55054 (ATG16L1), 77040 (Atg16l1)

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Eq (Equine), Rb (Rabbit), GP (Guinea Pig), Prim (Primate)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Dot blot (Dot), Paraffin Sections (P), Immunoprecipitation (IP)

Background of APG16L / ATG16L1 antibody

Atg16L1 (autophagy-related protein 16-1) forms a component of a protein complex that directs LC3 to autophagosomes en route to their fusion with lysosomes, thereby playing a key role in the process of autophagosome maturation. Atg16L1 belongs to WD repeat ATG16 family, exist as homooligomer and interacts with ATG5 as well as RAB33B, and forms a part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kD) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kD). It is found in cytoplasm and gets localized to preautophagosomal structure where it is implicated in the membrane targeting of ATG5. Mice deficient in Atg16L1 (Atg16L1HM) display reduced autophagy and develop, on viral infection, intestil abnormalities similar to pathologies found in Crohn's disease patients, including abnormalities in the integrity, architecture, and function of Paneth cells, which are specialized secretory epithelial cells of the small intestine. Atg16L1 has also been shown to play a role in modulating proinflammatory responses and population genetic studies have positively linked a common polymorphism in ATG16L1 gene with inflammatory bowel disease type 10 (IBD10).

General readings

1. Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR.
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007 May;39(5):596-604. Epub 2007 Apr 15.
PMID: 17435756

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APG16L / ATG16L1 (84-114) antibody

  Rabbit polyclonal ATG16L Antibody  
Western blot of APG16L (L92) Pab (Cat. #TA324639) in mouse brain tissue lysate. Rabbit Ig Purified Hu, Ms ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 (N-term) antibody

  Rabbit Polyclonal ATG16 Antibody  
Western blot analysis of ATG16 in HeLa cell lysate with ATG16 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 (Center) antibody

  Rabbit Polyclonal ATG16 Antibody  
Western blot analysis of ATG16 in HeLa cell lysate with ATG16 antibody at (A) 0.25 and (B) 0.5 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Goat Anti-ATG16L1 Antibody  
(0.1ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Rabbit polyclonal anti-ATG16L1 antibody  
Western blot analysis of extracts from Jurkat cells, using ATG16L1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Rabbit anti-ATG16L1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ATG16L1 antibody. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Rabbit Polyclonal Anti-ATG16L1 Antibody  
WB Suggested Anti-ATG16L1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Rabbit Polyclonal Anti-ATG16L1 Antibody  
WB Suggested Anti-ATG16L1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human brain Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Rabbit Polyclonal Anti-ATG16L1 Antibody  
WB Suggested Anti-ATG16L1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Rabbit Polyclonal ATG16L1 Antibody  
Western Blot: ATG16L1 Antibody [TA336540] - Detection of ATG16L1 using TA336540 in HCT116 whole cell extracts. Image from verified customer review. Rabbit Purified Bov, Can, Hu, Ms, Prim, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 antibody

  Rabbit Polyclonal ATG16L1 Antibody  
Western Blot: ATG16L1 Antibody [TA336555] - Analysis of ATG16L1 in HeLa whole cell extracts. Rabbit Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APG16L / ATG16L1 (N-term) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with ATG16L1 antibody AP22610PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

APG16L / ATG16L1 antibody

Human Placenta (formalin-fixed, paraffin-embedded) stained with ATG16L1 antibody AP22611PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

APG16L / ATG16L1 (C-term) antibody

Western blot analysis using Autophagy APG16L Antibody Cat.-No AP32204PU-N (C-term) in NIH-3T3, HepG2, Hela, Jurkat and NCI-H460 cell line lysates (35 µg/lane). Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Atg16l1 - mouse gene knockout kit via CRISPR

Atg16l1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Atg16l1 - mouse gene knockout kit via CRISPR

Atg16l1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ATG16L1 (mGFP-tagged) - Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATG16L1 (mGFP-tagged) - Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,260.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATG16L1 (mGFP-tagged)-Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATG16L1 (mGFP-tagged)-Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATG16L1 (mGFP-tagged) - Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATG16L1 (mGFP-tagged) - Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €1,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATG16L1 (Myc-DDK tagged) - Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ATG16L1 (Myc-DDK tagged) - Human ATG16 autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,130.00
  OriGene Technologies, Inc.

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