APH1B antibody

Principal name

APH1B antibody

Alternative names for APH1B antibody

Gamma-secretase subunit APH-1B, PSFL, Aph-1beta, Presenilin-stabilization factor-like

Gene ID

83464 (APH1B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts


Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of APH1B antibody

Anterior pharynx defective 1 (Aph-1) is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, and is involved in multiple neurodevelopmental signaling pathways. Aph-1b and Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, such as schizophrenia.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APH1B antibody

Host: Rabbit; Target Name: APH1B; Sample Tissue: Lung Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

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