APOER2 / LRP8 antibody

Principal name

APOER2 / LRP8 antibody

Alternative names for APOER2 / LRP8 antibody

Apolipoprotein E receptor 2, Low-density lipoprotein receptor-related protein 8

SwissProt ID

Q14114 (Human), Q924X6 (Mouse), Q98931 (Chick)

Gene ID

7804 (LRP8), 6937804 (aas), 16975

Available reactivities

Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish), Eq (Equine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunohistochemistry (IHC)

Background of APOER2 / LRP8 antibody

ApoER2 (apolipoprotein E receptor 2 or LDL receptor related protein 8) is a member of LDL receptor (LDLR) family and it acts as a cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. ApoER2 facilitates extracellular RELN sigl transduction to intracellular sigling processes, mainly through binding with DAB1 on its cytoplasmic tail. RELN acts via both VLDLR and ApoER2 to regulate tyrosine phosphorylation mediated DAB1 activation and microtubule function in neurol cells. ApoER2 possess higher affinity for RELN compared to VLDLR and is therefore, a key player in Reelin pathway that governs forebrain's neurol layering during pretal brain development. ApoER2 associates with ER resident receptor-associated protein (RAP) as well as with dimers of beta 2-glycoprotein I. In the vasculature, ApoER2 has been suggested to implicate in suppressing platelet aggregation. Moreover, ApoER2 is highly expressed in epididymis (initial segment), where it affects the functiol expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), which are required for sperm maturation. ApoER2 also function as an endocytic receptor and defective ApoER2 have been linked to myocardial infarction type 1 (MCI1).

General readings

Hoe,H.S., (2008) J. Biol. Chem. 283 (10), 6288-6299

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APOER2 / LRP8 antibody

Anti-LRP8 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit Purified Hu E, P
50 µg / €345.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

Western blot analysis of extracts from Jurkat cells, using LRP8 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

APOER2 / LRP8 Rabbit IgG Purified Bov, Eq, Hu, Ms, Por, Rb, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

WB Suggested Anti-LRP8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Transfected 293T Rabbit IgG Purified Can, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

Western Blot: ApoER2 Antibody [TA336282] - Analysis of ApoER2 on mouse brain membrane. Rabbit Purified Chk, Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

Western Blot: ApoER2 Antibody [TA336283] - Detection of ApoER2 in mouse brain membrane lysate using NB 100-2217. ECL exposure, 1 min. Rabbit Purified Bov, Chk, Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

APOER2 / LRP8 antibody

LRP8 polyclonal antibody (A01), Lot # 051007JC01 Western Blot analysis of LRP8 expression in SJCRH30 ( Cat # L027V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

APOER2 / LRP8 antibody

Detection limit for recombinant GST tagged LRP8 is approximately 0.03ng/ml as a capture antibody. Mouse IgG1 3H2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

APOER2 / LRP8 antibody

APOER2 / LRP8 Mouse IgG1 1A1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

APOER2 / LRP8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with LRP8 polyclonal antibody ( Cat # PAB4740 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

APOER2 / LRP8 antibody

Western blot analysis of LRP8 in mouse brain lysate using LRP8 polyclonal antibody ( Cat # PAB12395 ). Rabbit Chk, Hu, Ms WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

APOER2 / LRP8 antibody

Western blot analysis of LRP8 in mouse brain membrane lysate using LRP8 polyclonal antibody ( Cat # PAB12396 ). Rabbit Bov, Chk, Hu, Ms WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

APOER2 / LRP8 antibody

Human brain; Anti-LRP8 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.; LRP8 antibody - middle region (ARP44723_P050) in Human brain cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

APOER2 / LRP8 antibody

Western blot analysis of Apolipoprotein E Receptor 2 expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

APOER2 / LRP8 antibody

Western blot analysis of Apolipoprotein E Receptor 2 expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

APOER2 / LRP8 antibody

Western blot analysis of Apolipoprotein E Receptor 2 expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

APOER2 / LRP8 antibody

APOER2 / LRP8 Mouse IgG2b ER2-LB3-8G7 Purified Hu ELISA, IHC
50 µg / €640.00
  Funakoshi Co., Ltd.

APOER2 / LRP8 antibody

APOER2 / LRP8 Mouse IgG2b ER2-LB3-10B6 Purified Hu IHC, WB
50 µg / €640.00
  Funakoshi Co., Ltd.

APOER2 / LRP8 antibody

APOER2 / LRP8 Mouse IgG1 ER2-CyA1D9 Purified Hu IHC, WB
50 µg / €640.00
  Funakoshi Co., Ltd.

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