APOER2 / LRP8 antibody

Principal name

APOER2 / LRP8 antibody

Alternative names for APOER2 / LRP8 antibody

Apolipoprotein E receptor 2, Low-density lipoprotein receptor-related protein 8

SwissProt ID

Q14114 (Human), Q924X6 (Mouse), Q98931 (Chick)

Gene ID

7804 (LRP8), 16975 (Lrp8)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), Por (Porcine), Rb (Rabbit), Sh (Sheep), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunohistochemistry (IHC), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of APOER2 / LRP8 antibody

ApoER2 (apolipoprotein E receptor 2 or LDL receptor related protein 8) is a member of LDL receptor (LDLR) family and it acts as a cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. ApoER2 facilitates extracellular RELN sigl transduction to intracellular sigling processes, mainly through binding with DAB1 on its cytoplasmic tail. RELN acts via both VLDLR and ApoER2 to regulate tyrosine phosphorylation mediated DAB1 activation and microtubule function in neurol cells. ApoER2 possess higher affinity for RELN compared to VLDLR and is therefore, a key player in Reelin pathway that governs forebrain's neurol layering during pretal brain development. ApoER2 associates with ER resident receptor-associated protein (RAP) as well as with dimers of beta 2-glycoprotein I. In the vasculature, ApoER2 has been suggested to implicate in suppressing platelet aggregation. Moreover, ApoER2 is highly expressed in epididymis (initial segment), where it affects the functiol expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), which are required for sperm maturation. ApoER2 also function as an endocytic receptor and defective ApoER2 have been linked to myocardial infarction type 1 (MCI1).

General readings

Hoe,H.S., (2008) J. Biol. Chem. 283 (10), 6288-6299

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APOER2 / LRP8 antibody

  APOER2 / LRP8 Rabbit Polyclonal Antibody  
Anti-LRP8 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit Purified Hu E, P
50 µg / €400.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

  Rabbit polyclonal LRP8 antibody  
Western blot analysis of extracts from Jurkat cells, using LRP8 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

  Rabbit Polyclonal Anti-Lrp8 Antibody  
APOER2 / LRP8 Rabbit IgG Purified Bov, Eq, Hu, Ms, Por, Rb, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

  Rabbit Polyclonal Anti-LRP8 Antibody  
WB Suggested Anti-LRP8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Transfected 293T Rabbit IgG Purified Can, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

  Rabbit Polyclonal Apolipoprotein E R2/ApoE R2 Antibody  
Western Blot: ApoER2 Antibody [TA336282] - Analysis of ApoER2 on mouse brain membrane. Rabbit Purified Chk, Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 antibody

  Rabbit Polyclonal Apolipoprotein E R2/ApoE R2 Antibody  
Western Blot: ApoER2 Antibody [TA336283] - Detection of ApoER2 in mouse brain membrane lysate using NB 100-2217. ECL exposure, 1 min. Rabbit Purified Bov, Chk, Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

APOER2 / LRP8 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Lrp8 - mouse gene knockout kit via CRISPR

Lrp8 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Lrp8 - mouse gene knockout kit via CRISPR

Lrp8 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lrp8 - mouse gene knockout kit via CRISPR

Lrp8 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lrp8 - mouse gene knockout kit via CRISPR

Lrp8 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

APOER2 / LRP8 (transcript variant 3)

  Recombinant protein of human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 3  
APOER2 / LRP8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

APOER2 / LRP8

APOER2 / LRP8 Human Purified > 90 % CHO cells
50 µg / €400.00
  Neuromics Antibodies

Lysates

Catalog No.    

LRP8 overexpression lysate

LRP8 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

LRP8 overexpression lysate

LRP8 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, LRP8 (mGFP-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, LRP8 (mGFP-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,710.00
  OriGene Technologies, Inc.

Lenti ORF particles, LRP8 (mGFP-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, LRP8 (mGFP-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,570.00
  OriGene Technologies, Inc.

Lenti ORF particles, LRP8 (Myc-DDK-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, LRP8 (Myc-DDK-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,790.00
  OriGene Technologies, Inc.

Lenti ORF particles, LRP8 (Myc-DDK-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, LRP8 (Myc-DDK-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,540.00
  OriGene Technologies, Inc.

Lenti ORF particles, LRP8 (Myc-DDK-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, LRP8 (Myc-DDK-tagged)-Human low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (LRP8), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,410.00
  OriGene Technologies, Inc.

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