Apolipoprotein B / Apo B antibody

Principal name

Apolipoprotein B / Apo B antibody

Alternative names for Apolipoprotein B / Apo B antibody

ApoB, Apo-B, ApoB100, ApoB-100

SwissProt ID

P04114 (Human), P11682 (Chick), P17165 (Rabit), Q7TMA5 (Rat)

Gene ID

338 (APOB)

Available reactivities

Hu (Human), Ms (Mouse), GP (Guinea Pig), Por (Porcine), Rt (Rat), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat, Sheep, Chicken

Available applications

Enzyme Immunoassay (E), Radioimmunoassay (R), Immunodiffusion (ID), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Dot blot (Dot), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Apolipoprotein B / Apo B antibody

Lipids (triglyceride (TG), cholesterol (Chol), phospholipids (PL), cholesteryl esters (CE)) are insoluble in plasma. These lipids combine with apolipoproteins to form lipoproteins. This process solubilizes lipids in plasma. Lipoproteins provide a transport system for lipids. They also play an important role in lipoprotein receptor recognition and regulation of certain enzymes in lipoprotein metabolism. Apolipoprotein B plays an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis. Apo B is the major protein moiety of all lipoproteins other than high density lipoprotein (HDL) in plasma. Increased levels of apo B100 are associated with an increased risk of coronary artery disease. Apo B exists in human plasma as two isoforms: apo B48 and apo B100. Apo B100 is the major physiological ligand for the LDL receptor. It contains 4536 amino acid residues (Chen et al., 1986; Law et al., 1986). Apo B100 is the full length protein. Its gene has been mapped on the short arm of chromosome 2, with an approximate length of 43 kilobases and 29 exons (Ludwig, et al., 1987). The LDL-binding domain of the molecule is proposed to be located between the aa3129-3532 (Knott, et al., 1986). Apo B100 is synthesised in the liver. It is required for the assembly of very low density lipoproteins (VLDL).

General readings

Valentinova, N.V., et al., 1994, Biol. Chem. 375, 651-658, Hoppe-Seyler.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG1 4C11 Purified Hu C, E
1 ml / €370.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Immunofluorescence analysis of HepG2 cells using ApoB mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Mouse IgG1 6G6 Ascites Hu E, ICC/IF, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

TA305876 (0.5ug/ml) staining of Human Serum lysates. Data kindly provided by Yan Xie and NO Davidson, Washington USA. This antibody showed background below 150kDa in serum samples . We call for caution when used for other assays than Western blot. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Apolipoprotein B / Apo B antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and thyroid cancer tissue . Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using APOB antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Apolipoprotein B / Apo B antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and thyroid cancer tissue . Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using APOB antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG1 1609 Purified Hu E, R
1 mg / €570.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG2b 057-10035 Purified Hu E, R
1 mg / €310.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG2b 057-10034 Purified Hu E, R
1 mg / €310.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG2b 057-10031 Purified Hu E, R
1 mg / €310.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG1 2E3 Purified Hu C, E
1 ml / €370.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG1 12G10 Purified Hu C, E
1 ml / €370.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG1 5F8 Purified Hu C, E
1 ml / €370.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Goat IgG Purified Hu E, IP, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Human Liver (formalin-fixed, paraffin-embedded) stained with APOB antibody AP22472PU-Nat 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat IgG Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Human Liver (formalin-fixed, paraffin-embedded) stained with APOB antibody AP22590PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Purified Hu E, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Purified Hu E, IP, P, WB
50 µg / €460.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG2b 1605 Purified Hu E, R
1 mg / €410.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG1 1610 Purified Hu E, R
1 mg / €410.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Mouse IgG2a 1606 Purified Hu E
1 mg / €410.00
  Acris Antibodies GmbH

Apolipoprotein B / Apo B antibody

Apolipoprotein B / Apo B Rabbit Serum Hu, Ms ID, WB
1 ml / €320.00
  Acris Antibodies GmbH

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