Aquaporin-0 / AQP0 antibody

Principal name

Aquaporin-0 / AQP0 antibody

Alternative names for Aquaporin-0 / AQP0 antibody

MP26, MIP, MIP26, Lens fiber major intrinsic protein

SwissProt ID

A2IBY8 (Canfa), P06624 (Bovin), P09011 (Rat), P30301 (Human), P51180 (Mouse)

Gene ID

4284 (MIP), 17339 (Mip)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of Aquaporin-0 / AQP0 antibody

Aquaporins (AQPs) are a large family of integral membrane channel proteins that facilitate the transport of water through the cell membrane. Aquaporins are widely distributed and are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor. AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-Calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-0 / AQP0 antibody

  Anti-AQP0 Rabbit Polyclonal Antibody  
Western blot analysis of Mouse eyes tissue using TA322423(MIP Antibody) at dilution 1/150 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Aquaporin-0 / AQP0 antibody

Immunohistochemistry analyzes of AP20629PU-N AQP0 antibody (Cat.-No.: AP20629PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €370.00
  OriGene Technologies GmbH

2 Item(s)

per page
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