Aquaporin-1 / AQP1 antibody

Principal name

Aquaporin-1 / AQP1 antibody

Alternative names for Aquaporin-1 / AQP1 antibody

AQP-1, CHIP28, Aquaporin-CHIP, Water channel protein for red blood cells and kidney proximal tubule, Urine water channel

SwissProt ID

P29972 (Human), P29975 (Rat), P47865 (Bovin), Q02013 (Mouse), Q6PQZ1 (Pig), Q9N2J4 (Canfa)

Gene ID

358 (AQP1), 25240 (Aqp1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Sh (Sheep), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of Aquaporin-1 / AQP1 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amino acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are at least 12 isoforms of Aquaporins area cloned.
Acetazolamide can bind to Aquaporin 1 and inhibit the water movement across theplasma mmbrane. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP1 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. AQP1 may also play a role in tumor angiogenesis and in the development of effusions or edema fluid.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-1 / AQP1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-AQP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502357) Mouse IgG1 OTI2D10 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Aquaporin-1 / AQP1 antibody

Western blot analysis of extracts from rat brain cells, using AQP1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-1 / AQP1 antibody

Predicted cell location: Cell membrane, Cytoplasm. Positive control: Human stomach cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human stomach cancer tissue using AQP1 antibody at dilution 1/5, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-1 / AQP1 antibody

Predicted cell location: Cell membrane, Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using AQP1 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-1 / AQP1 antibody

Western blot analysis of Aquaporin 1in rat kidney tissue using a 1 in 2000 dilution of the antibody Rabbit Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-1 / AQP1 antibody

Western blot analysis of rat kidney membranes: 1. Anti-Aquaporin 1 antibody, (1:400). 2. Anti-Aquaporin 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-1 / AQP1 antibody

Western blot analysis of AQP1 expression in rat brain Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Aquaporin-1 / AQP1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY AQP1 (RC205304, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AQP1. Mouse IgG1 OTI10C11 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Aquaporin-1 / AQP1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY AQP1 (RC205304, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AQP1. Mouse IgG1 OTI1F3 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Aquaporin-1 / AQP1 control peptide

Aquaporin-1 / AQP1
0.25 mg / €250.00
  Acris Antibodies GmbH

Aquaporin-1 / AQP1 (C-term amidated) antibody

Aquaporin-1 / AQP1 Rabbit Aff - Purified Bov, Hu, Ms, Rt, Sh E, ICC/IF, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Aquaporin-1 / AQP1 (C-term) antibody

Immunohistochemical analysis of paraffin embedded mammary cancer sections, staining AQP1 in cytoplasm, DAB chromogenic reaction Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Aquaporin-1 / AQP1 (249-269) antibody

Aquaporin-1 / AQP1 Mouse IgG1 1/A5F6 Purified Hu, Ms, Rt C, E, IP, P, WB
0.1 mg / €670.00
  Acris Antibodies GmbH

Aquaporin-1 / AQP1 antibody

Aquaporin-1 / AQP1 Mouse IgG2b 7D11 Purified Hu, Ms, Rt C, E, IP, P, WB
0.1 mg / €670.00
  Acris Antibodies GmbH

Aquaporin-1 / AQP1 antibody

Aquaporin-1 / AQP1 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Aquaporin-1 / AQP1 antibody

Aquaporin-1 / AQP1 Mouse IgG1 1/A5F6 Hu, Ms, Rt C, E, IP, P, WB
0.1 mg / €990.00
  Abnova Taiwan Corp.

Aquaporin-1 / AQP1 antibody

Western blot analysis of extracts from rat brain cells, using AQP1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

Aquaporin-1 / AQP1 antibody

Western blot analysis of extracts from rat brain cells, using AQP1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Aquaporin-1 / AQP1 antibody

Aquaporin-1 / AQP1 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Aquaporin-1 / AQP1 antibody

Western blot analysis of Aquaporin 1 expression in A549 (A); mouse liver (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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