Aquaporin-11 / AQP11 antibody

Principal name

Aquaporin-11 / AQP11 antibody

Alternative names for Aquaporin-11 / AQP11 antibody

AQP-11, AQPX1

SwissProt ID

Q8BHH1 (Mouse), Q8CHM1 (Rat), Q8NBQ7 (Human)

Gene ID

66333 (Aqp11), 282679 (AQP11), 286758

Available reactivities

Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of Aquaporin-11 / AQP11 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amino acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are at least 12 isoforms of Aquaporins are cloned. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. Aquaporins are characterized by presence of highly conserved asparagine proline alanine (NPA) boxes that are important for the formation of a water-permeating pore. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP9 may be responsible for tumor angiogenesis and in the development of effusions or edema fluid and led to high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas
The expression of AQP11 is found in multiple rat tissues, including kidney, liver, testes and brain. AQP11 has a unique distribution in brain, appearing in Purkinje cell dendrites, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons. Immunofluorescent staining of Purkinje cells indicates that AQP11 is intracellular. Unlike other aquaporins, Xenopus oocytes expressing AQP11 in the plasma membrane failed to transport water, glycerol, urea, or ions. AQP11 is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily. The aquaporin 11 and 12 are localized intracellularly and have positively charged amino acid clusters at the C-terminal end identical to di-lysine (KKXX) motif for an endoplasmic retention signal. Disruption of Aquaporin 11 led to fatal polycystic kidneys (4). Further studies are necessary to elucidate the role of AQP11 in the brain (3).

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-11 / AQP11 antibody

  Rabbit polyclonal Anti-Aquaporin 11 (extracellular)  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1-2. Anti-Aquaporin 11 (extracellular) antibody , (1:1000). 3-4. Anti-Aquaporin 11 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

AQP11 - human gene knockout kit via CRISPR

AQP11 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AQP11 - human gene knockout kit via CRISPR

AQP11 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AQP11 - human gene knockout kit via CRISPR

AQP11 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AQP11 - human gene knockout kit via CRISPR

AQP11 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aqp11 - mouse gene knockout kit via CRISPR

Aqp11 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Aqp11 - mouse gene knockout kit via CRISPR

Aqp11 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aqp11 - mouse gene knockout kit via CRISPR

Aqp11 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aqp11 - mouse gene knockout kit via CRISPR

Aqp11 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

AQP11 overexpression lysate

AQP11 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AQP11 (mGFP-tagged) - Human aquaporin 11 (AQP11), 200 uL, >10^7 TU/mL

Lenti ORF particles, AQP11 (mGFP-tagged) - Human aquaporin 11 (AQP11), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, AQP11 (Myc-DDK tagged) - Human aquaporin 11 (AQP11) , 200 uL, >10^7 TU/mL

Lenti ORF particles, AQP11 (Myc-DDK tagged) - Human aquaporin 11 (AQP11) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Aqp11 (GFP-tagged ORF) - Rat aquaporin 11 (Aqp11), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp11 (GFP-tagged ORF) - Rat aquaporin 11 (Aqp11), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aqp11 (Myc-DDK-tagged ORF) - Rat aquaporin 11 (Aqp11), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp11 (Myc-DDK-tagged ORF) - Rat aquaporin 11 (Aqp11), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

14 Item(s)

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