Aquaporin-2 / AQP2 antibody

Principal name

Aquaporin-2 / AQP2 antibody

Alternative names for Aquaporin-2 / AQP2 antibody

Aquaporin-CD, AQP-CD, WCH-CD, Collecting duct water channel protein, Water channel protein for renal collecting duct, ADH water channel

SwissProt ID

P34080 (Rat), P41181 (Human), P56402 (Mouse), P79099 (Bovin), P79144 (Canfa), P79213 (Rabit)

Gene ID

11827 (Aqp2), 25386, 359 (AQP2)

Available reactivities

Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Mky (Monkey), Ms (Mouse), Sh (Sheep), Por (Porcine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F)

Background of Aquaporin-2 / AQP2 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amino acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are atlest 12 isoforms of Aquaporins area cloned.
Acetazolamide can bind to Aquaporin 1 and inhibit the water movement across the plasma membrane. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extra-cellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP1 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. AQP1 may also play a role in tumor angiogenesis and in the development of effusions or edema fluid.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-2 / AQP2 (237-255, C-term) antibody

Western blot analysis of Aquaporin 2 in rat kidney tissue using a 1 in 2000 dilution of the antibody Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-2 / AQP2 pSer261 antibody

Figure 1. Western blot of rat kidney lysate showing specific immunolabeling of the ~29k and 37k glycosylated form of the AQP2 protein phosphorylated at Ser261.    Immunolabeling is  blocked  by the phospho-peptide  used as antigen (peptide) but not by the corresponding dephospho-peptide (not shown). Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt C, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Aquaporin-2 / AQP2 pSer264 antibody

Western blot of vasopressin (AVP) treated Rat kidney lysate showing specific immunolabeling of the ~ 29k and 37k glycosylated form of the AQP2 protein phosphorylated at Ser264. Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt C, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Aquaporin-2 / AQP2 pSer269 antibody

Western blot of vasopressin (AVP) treated Rat kidney lysate showing specific immunolabeling of the ~ 29k and 37k glycosylated form of the AQP2 protein phosphorylated at Ser269. Rabbit IgG Aff - Purified Bov, Can, Ms, Rt C, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Aquaporin-2 / AQP2 antibody

Western blot: Aquaporin 2 Antibody -Detection of Aquaporin 2 in rat kidney extracts  Key: CX=Cortex, OM=Outer Medulla, IMB =Inner Medulla Base, IMP = Inner Medulla Papilla Rabbit Purified Bov, Hu, Ms, Por, Rt, Sh C, ICC/IF, WB
50 µl / €325.00
  OriGene Technologies, Inc.

Aquaporin-2 / AQP2 antibody

Predicted cell location: Cytoplasm, Nucleus. Positive control: Human tonsil and liver cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using AQP2 antibody at dilution 1/100, on the right is treated with the synthetic peptide. (Original magnification:x 400) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-2 / AQP2 antibody

Predicted cell location: Cytoplasm, Nucleus . Positive control: Human renal cancer tissue. Recommended dilution: 1/50-200.The image is immunohistochemistry of paraffin-embedded Human renal cancer tissue using AQP2 antibody at dilution 1/50. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-2 / AQP2 antibody

Western blot analysis of AQP2 in A431 cell lysate with AQP2 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Aquaporin-2 / AQP2 antibody

Western blot analysis of rat kidney membranes: 1. Anti-Aquaporin 2 antibody , (1:200). 2. Anti-Aquaporin 2 antibody, preincubated with a control peptide antigen. Rabbit Purified Hu, Ms, Rt P, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-2 / AQP2 antibody

WB Suggested Anti-Aqp2 Antibody Titration: 0.2-1ug/mL; ELISA Titer: 1:62500; Positive Control: Mouse Heart Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Aquaporin-2 / AQP2 pSer261 antibody

Aquaporin-2 / AQP2 Rabbit IgG Purified Bov, Can, Chk, Hu, Mky, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

Aquaporin-2 / AQP2 (N-term) antibody

Kidney: Formalin-Fixed Paraffin Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Aquaporin-2 / AQP2 control peptide

Aquaporin-2 / AQP2
0.25 mg / €250.00
  Acris Antibodies GmbH

Aquaporin-2 / AQP2 (C-term amidated) antibody

Aquaporin-2 / AQP2 Rabbit Aff - Purified Bov, Hu, Ms, Rt, Sh E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Aquaporin-2 / AQP2 antibody

Aquaporin-2 / AQP2 Rabbit Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Aquaporin-2 / AQP2 antibody

Aquaporin-2 / AQP2 Rabbit Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Aquaporin-2 / AQP2 antibody

Western blot of rat kidney lysate showing specific immunolabeling of the ~ 29k and 37k glycosylated form of the Aqp2 protein phosphorylated at Ser261. Immunolabeling is blocked by the phospho-peptide used as antigen (peptide) but not by the corresponding dephospho-peptide (not shown). Rabbit Bov, Chk, Hu, Ms, Rt WB
0.1 ml / €510.00
  Abnova Taiwan Corp.

Aquaporin-2 / AQP2 antibody

Staining of Aqp2 on mpkCCD cell line using Aqp2 polyclonal antibody ( Cat # PAB12114 ). Rabbit Bov, Hu, Ms, Rt, Sh ICC/IF, WB
50 µl / €470.00
  Abnova Taiwan Corp.

Aquaporin-2 / AQP2 pSer256 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Aquaporin 2 (Phospho-Ser256) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

Aquaporin-2 / AQP2 pSer256 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Aquaporin 2 (Phospho-Ser256) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

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