Aquaporin-4 / AQP4 antibody

Principal name

Aquaporin-4 / AQP4 antibody

Alternative names for Aquaporin-4 / AQP4 antibody

AQP-4, WCH4, MIWC, Mercurial-insensitive water channel

SwissProt ID

O77750 (Bovin), P47863 (Rat), P55087 (Human), P55088 (Mouse)

Gene ID

361 (AQP4), 25293 (Aqp4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Sh (Sheep), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Aquaporin-4 / AQP4 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amino acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are atlest 12 isoforms of Aquaporins area cloned.
Acetazolamide can bind to Aquaporin 1 and inhibit the water movement across the plasma membrane. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP1 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. AQP1 may also play a role in tumor angiogenesis and in the development of effusions or edema fluid.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-4 / AQP4 antibody

Aquaporin-4 / AQP4 Mouse IgG1 3D2 Purified Hu C, E, IP, P, WB
0.1 mg / €670.00
  Acris Antibodies GmbH

Aquaporin-4 / AQP4 antibody

Aquaporin-4 / AQP4 Mouse IgG1 3D2 Purified Hu C, E, IP, P, WB
20 µg / €280.00
  Acris Antibodies GmbH

Aquaporin-4 / AQP4 antibody

Western blot analysis of Mouse heart tissue using TA323133(AQP4 Antibody) at dilution 1/200 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-4 / AQP4 antibody

Western blot analysis of Aquaporin 4 in rat kidney lysates using a 1:2000 dilution of the antibody Rabbit Purified Hu, Ms ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-4 / AQP4 antibody

Western blot analysis of rat brain membranes: 1. Anti-Aquaporin 4 (249-323) antibody , (1:1000). 2. Anti-Aquaporin 4 (249-323) antibody, preincubated with the control fusion protein. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-4 / AQP4 antibody

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1, 2. Anti-Aquaporin 4 (300-314) antibody , (1:200). 3, 4. Anti-Aquaporin 4 (300-314) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-4 / AQP4 antibody

Western blot analysis of extracts of various cell lines, using AQP4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Aquaporin-4 / AQP4 control peptide

Aquaporin-4 / AQP4
0.25 mg / €250.00
  Acris Antibodies GmbH

Aquaporin-4 / AQP4 (C-term amidated) antibody

Aquaporin-4 / AQP4 Rabbit Aff - Purified Bov, Hu, Ms, Rt, Sh E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Aquaporin-4 / AQP4 antibody

Immunohistochemistry analysis of AQP4 Antibody (Cat.-No AP20566PU-N) in Paraffin-Embedded Human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Aquaporin-4 / AQP4 (C-term) antibody

AQP4 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Aquaporin-4 / AQP4 antibody

Western Blot analysis of AQP4 expression from rat brain tissue lyate with AQP4 polyclonal antibody ( Cat # PAB12309 ). Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Aquaporin-4 / AQP4 antibody

Aquaporin-4 / AQP4 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

Aquaporin-4 / AQP4 antibody

Aquaporin-4 / AQP4 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Aquaporin-4 / AQP4 antibody

Immunohistochemical analysis of Aquaporin 4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Aquaporin-4 / AQP4 antibody

Immunohistochemical analysis of Aquaporin 4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Aquaporin-4 / AQP4 antibody

Immunohistochemical analysis of Aquaporin 4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Aquaporin-4 / AQP4 antibody

Western blot analysis of Aquaporin 4 expression in Hela (A); mouse heart (B); rat heart (C) whole cell lysates. Mouse Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Aquaporin-4 / AQP4 antibody

Western blot analysis of Aquaporin 4 expression in Hela (A); mouse heart (B); rat heart (C) whole cell lysates. Mouse Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Aquaporin-4 / AQP4 antibody

Western blot analysis of Aquaporin 4 expression in Hela (A); mouse heart (B); rat heart (C) whole cell lysates. Mouse Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

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