Aquaporin-6 / AQP6 antibody

Principal name

Aquaporin-6 / AQP6 antibody

Alternative names for Aquaporin-6 / AQP6 antibody

AQP-6, AQP2L, Aquaporin-2-like, hKID, Kidney-specific aquaporin

SwissProt ID

Q13520 (Human), Q8C4A0 (Mouse), Q9WTY0 (Rat)

Gene ID

363 (AQP6), 29170 (Aqp6)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Aquaporin-6 / AQP6 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amino acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are at least 12 isoforms of Aquaporins area cloned. AQP6 is located on human 12q13 chromosome and exhibit significant homology with other aquaporin protein.
Acetazolamide can bind to Aquaporin 1 and inhibit the water movement across the plasma membrane. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP6 is expressed in intracellular vesicles and have shown to have high affinity for nitrates transport across the membrane (2) and may be responsible for the high vascular permeability for nitrates. AQP1 may also play a role in tumor angiogenesis and in the development of effusions or edema fluid.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-6 / AQP6 antibody

Western blot analysis of rat kidney membranes: 1. Anti-Aquaporin 6 antibody , (1:200). 2. Anti-Aquaporin 6 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-6 / AQP6 control peptide

Aquaporin-6 / AQP6
0.25 mg / €250.00
  Acris Antibodies GmbH

Aquaporin-6 / AQP6 (C-term amidated) antibody

Aquaporin-6 / AQP6 Rabbit Aff - Purified Bov, Hu, Ms, Rt, Sh E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Aquaporin-6 / AQP6 antibody

Aquaporin-6 / AQP6 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Aquaporin-6 / AQP6 antibody

Aquaporin-6 / AQP6 Rabbit IgG Aff - Purified Hu P, WB
0.1 mg / €290.00
  Boster Immunoleader


Catalog No.    

AQP6 overexpression lysate

AQP6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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