Aquaporin-7 / AQP7 antibody

Principal name

Aquaporin-7 / AQP7 antibody

Alternative names for Aquaporin-7 / AQP7 antibody

AQP-7, AQP7L, AQP9, Aquaporin adipose, Aquaporin-7-like, AQPAP

SwissProt ID

O14520 (Human), O54794 (Mouse), P56403 (Rat)

Gene ID

364 (AQP7), 29171 (Aqp7), 11832

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Aquaporin-7 / AQP7 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amio acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are atlest 12 isoforms of Aquaporins area cloned.
Acetazolamide can bind to Aquaporin 1 and inhibit the water movement across the plasma membrane. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP1 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. AQP1 may also play a role in tumor angiogenesis and in the development of effusions or edema fluid.

General readings

Kondo,H., et al., (2002) Eur. J. Biochem. 269 (7), 1814-1826

16 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-7 / AQP7 antibody

  Rabbit polyclonal Anti-Aquaporin 7  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) kidney membranes: 1, 2. Anti-Aquaporin 7 antibody, , (1:500). 3, 4. Anti-Aquaporin 7 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt ICC/IF, P, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-7 / AQP7 antibody

  Rabbit Polyclonal Anti-AQP7 Antibody  
WB Suggested Anti-AQP7 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human heart Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

AQP7 - human gene knockout kit via CRISPR

AQP7 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AQP7 - human gene knockout kit via CRISPR

AQP7 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AQP7 - human gene knockout kit via CRISPR

AQP7 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AQP7 - human gene knockout kit via CRISPR

AQP7 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aqp7 - mouse gene knockout kit via CRISPR

Aqp7 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Aqp7 - mouse gene knockout kit via CRISPR

Aqp7 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Aquaporin-7 / AQP7

  Recombinant protein of human aquaporin 7 (AQP7)  
Aquaporin-7 / AQP7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

AQP7 overexpression lysate

AQP7 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AQP7 (mGFP-tagged) - Human aquaporin 7 (AQP7), 200 uL, >10^7 TU/mL

Lenti ORF particles, AQP7 (mGFP-tagged) - Human aquaporin 7 (AQP7), 200 uL, >10^7 TU/mL  
200 µl / €910.00
  OriGene Technologies, Inc.

Lenti ORF particles, AQP7 (Myc-DDK tagged) - Human aquaporin 7 (AQP7) , 200 uL, >10^7 TU/mL

Lenti ORF particles, AQP7 (Myc-DDK tagged) - Human aquaporin 7 (AQP7) , 200 uL, >10^7 TU/mL  
200 µl / €810.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Aqp7 (GFP-tagged) - Mouse aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp7 (GFP-tagged) - Mouse aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aqp7 (Myc-DDK-tagged) - Mouse aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp7 (Myc-DDK-tagged) - Mouse aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Aqp7 (GFP-tagged ORF) - Rat aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp7 (GFP-tagged ORF) - Rat aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aqp7 (Myc-DDK-tagged ORF) - Rat aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp7 (Myc-DDK-tagged ORF) - Rat aquaporin 7 (Aqp7), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

16 Item(s)

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