Aquaporin-8 / AQP8 antibody

Principal name

Aquaporin-8 / AQP8 antibody

Alternative names for Aquaporin-8 / AQP8 antibody

AQP-8

SwissProt ID

O94778 (Human), P56404 (Mouse), P56405 (Rat)

Gene ID

343 (AQP8), 29172 (Aqp8), 11833

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Ms (Mouse), Sh (Sheep)

Available hosts

Mouse, Chicken, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Aquaporin-8 / AQP8 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amio acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are atlest 12 isoforms of Aquaporins area cloned.
Acetazolamide can bind to Aquaporin 1 and inhibit the water movement across the plasma membrane. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP1 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. AQP1 may also play a role in tumor angiogenesis and in the development of effusions or edema fluid.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-8 / AQP8 antibody

  Rabbit polyclonal Anti-Aquaporin 8  
Western blot analysis of rat small intestine membranes: 1. Anti-Aquaporin 8 antibody , (1:200). 2. Anti-Aquaporin 8 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt P, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-8 / AQP8 antibody

  Anti-AQP8 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using AQP8 antibody at dilution 1/75, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-8 / AQP8 antibody

  Anti-AQP8 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using AQP8 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aquaporin-8 / AQP8 antibody

Human Colon, connective tissue: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1F8 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Aquaporin-8 / AQP8 antibody

Aquaporin-8 / AQP8 Chicken IgG Purified Rt E, WB
50 µg / €580.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

AQP8 - human gene knockout kit via CRISPR

AQP8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AQP8 - human gene knockout kit via CRISPR

AQP8 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AQP8 - human gene knockout kit via CRISPR

AQP8 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AQP8 - human gene knockout kit via CRISPR

AQP8 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

AQP8 overexpression lysate

AQP8 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Aqp8 (GFP-tagged) - Mouse aquaporin 8 (Aqp8), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp8 (GFP-tagged) - Mouse aquaporin 8 (Aqp8), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aqp8 (Myc-DDK-tagged) - Mouse aquaporin 8 (Aqp8), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp8 (Myc-DDK-tagged) - Mouse aquaporin 8 (Aqp8), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Aqp8 (GFP-tagged ORF) - Rat aquaporin 8 (Aqp8), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp8 (GFP-tagged ORF) - Rat aquaporin 8 (Aqp8), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aqp8 (Myc-DDK-tagged ORF) - Rat aquaporin 8 (Aqp8), 200 uL, >10^7 TU/mL

Lenti ORF particles, Aqp8 (Myc-DDK-tagged ORF) - Rat aquaporin 8 (Aqp8), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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