Aquaporin-9 / AQP9 antibody

Principal name

Aquaporin-9 / AQP9 antibody

Alternative names for Aquaporin-9 / AQP9 antibody

AQP-9, SSC1, Small solute channel 1

SwissProt ID

O43315 (Human), P56627 (Rat), Q9JJJ3 (Mouse)

Gene ID

366 (AQP9), 64008 (Aqp9), 65054

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Sh (Sheep)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C)

Background of Aquaporin-9 / AQP9 antibody

Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. These water channels also enhance cellular tolerance against rapid freezing, which suggest that they might have some ecological relevance also. Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amino acid protein from RBC and kidney libraries that has a 6 TMD (1). The amino terminal end of the protein was in the membrane and has 2 repeats that are at 180oto each other and are responsible for water selectivity. Now there are at least 12 isoforms of Aquaporins are cloned.
Aquaporin 9 (AQP9) is one of the recently identified water channels that is also permeable to neutral solutes including urea. AQP9 is expressed in humam amnion, chorion, and placenta (2). Transfection of AQP9 in promyelocytic leukemia cells (K562) exhibit higher mettaloid transport that are useful for leukemia treatment. Acetazolamide can bind to Aquaporin 1 and inhibit the water movement across the plasma membrane. In brain, three main AQPs AQP1, AQP4 and AQP9 are expressed and are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism (2). AQP1 and 4 are also implicated in water balance in retina and other eye components. Studies also suggest that AQP9 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. AQP9 may also play a role in tumor angiogenesis and in the development of effusions or edema fluid.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aquaporin-9 / AQP9 antibody

Western blot analysis of rat brain (lanes 1and 4), testis (lanes 2 and 5) and liver (lanes 3 and 6) membranes: 1,2,3. Anti-Aquaporin 9 antibody , (1:200). 4,5,6. Anti-Aquaporin 9 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt P, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Aquaporin-9 / AQP9 control peptide

Aquaporin-9 / AQP9
0.25 mg / €250.00
  Acris Antibodies GmbH

Aquaporin-9 / AQP9 (C-term amidated) antibody

Aquaporin-9 / AQP9 Rabbit Aff - Purified Bov, Hu, Ms, Rt, Sh E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Aquaporin-9 / AQP9 antibody

Aquaporin-9 / AQP9 Rabbit IgG Aff - Purified Ms WB
0.1 mg / €290.00
  Boster Immunoleader

Aquaporin-9 / AQP9 antibody

Aquaporin-9 / AQP9 Rabbit Hu P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Aquaporin-9 / AQP9

Aquaporin-9 / AQP9 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

AQP9 overexpression lysate

AQP9 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

7 Item(s)

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