ARFGEF1 antibody

Principal name

ARFGEF1 antibody

Alternative names for ARFGEF1 antibody

ARFGEP1, BIG1, p200 ARF-GEP1, Brefeldin A-inhibited GEP1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, p200 ARF guanine nucleotide exchange factor

SwissProt ID

O46382 (Bovin), Q9Y6D6 (Human)

Gene ID

10565 (ARFGEF1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of ARFGEF1 antibody

Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ARFGEF1 antibody

ARFGEF1 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

ARFGEF1 antibody

ARFGEF1 Mouse IgG2a 3E11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ARFGEF1 antibody

Immunohistochemistry-Paraffin: ARFGEF1 Antibody [NB100-55257] - Section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-BIG1/ARFGEF1 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit. Epitope Retrieval Buffer-High pH was substituted for Epitope Retrieval Buffer-Reduced pH. Rabbit Aff - Purified Hu, Ms ICC/IF, IP, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

ARFGEF1 antibody

Immunohistochemistry-Paraffin: ARFGEF1 Antibody [NBP1-88840] - Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

ARFGEF1 antibody

Immunohistochemistry-Paraffin: ARFGEF1 Antibody [NBP1-88841] - Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ARFGEF1

ARFGEF1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ARFGEF1

ARFGEF1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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