Arginase-1 antibody

Principal name

Arginase-1 antibody

Alternative names for Arginase-1 antibody

Type I arginase, Liver-type arginase, ARG1

SwissProt ID

P05089 (Human), P07824 (Rat), Q2KJ64 (Bovin), Q61176 (Mouse), Q95JC8 (Pig), Q95KM0 (Rabit)

Gene ID

383 (ARG1), 29221 (Arg1), 513608, 11846

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), African clawed frog, Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Ye (Yeast)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Flow Cytometry (F)

Background of Arginase-1 antibody

Arginase [EC 3.5.3.1; L-arginine aminohydrolase] is an enzyme that hydrolyzes Larginine to L-ornithine and urea in the urea cycle. Two forms of arginase exists which are designed as arginase I and arginase II. Livertype arginase I is expressed primarily in the liver and to some extend in the erythrocytes. Arginase II is expressed in many extrahepatic tissues, such as brain, spinal cord, kidney, small intestine and mammary gland. Although arginase I and arginase II have similar enzyme activities, they have different pI, immunological reactivity and are encoded by different genes. Human arginase I is a 35 kDa protein circulating in blood probably as a homotrimer. Circulating liver-type arginase was clinically used as a liver specific marker which may reflect not only early occurrence of liver injury but also early termination of liver injury. The measurement of liver-type arginase is clinically applicable for monitoring conditions of patients with liver disorders or pre- and postoperative conditions of patients who received partial hepatectomy with quicker normalization in comparison with aminotransferases (ALT and AST). Recently, arginase I gene was found to be one of the most prominent among astma genes. In situ hybridization demonstrated marked staining of arginase I in submucosal inflammatory lesions and arginase activity increased in allergen challenged lungs. Finally, it was found that both arginase I was the most significantly up-regulated protein in the murine spinal cord during experimental autoimmune encephalomyelitis. The results indicated that arginase I played important roles in autoimmune inflammation in the central nervous system.

General readings

1. Cardoso, M. L., Martins, E., Vasconcelos, R., Vilarinho, L., Rocha, J. Identification of a novel R21X
mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia. Hum.
Mutat. 14: 355-356, 1999.
2. Grody, W. W., Dodson, A., Klein, D., Kern, R. M., Bassand, P., Cederbaum, S. D. Molecular genetic
study of human arginase deficiency. (Abstract) Am. J. Hum. Genet. 45 (suppl.): A191 only, 1989.
3. Haraguchi, Y., Takiguchi, M., Amaya, Y., Kawamoto, S., Matsuda, I., Mori, M. Molecular cloning and
nucleotide sequence of cDNA for human liver arginase. Proc. Nat. Acad. Sci. 84: 412-415, 1987.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Arginase-1 antibody

  ARG1 (liver Arginase) mouse monoclonal antibody, clone OTI4E6 (formerly 4E6)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-ARG1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502413) Mouse IgG1 OTI4E6 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Arginase-1 antibody

  Rabbit Polyclonal antibody to Arginase I (arginase, liver)  
Sample (20 ug of whole cell lysate). A: mouse liver. 10% SDS PAGE. TA308162 diluted at 1:50000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Arginase-1 antibody

  Goat Polyclonal Antibody against ARG1  
TA303209 (0.03µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arginase-1 (C-term) antibody

  Goat Polyclonal Antibody against Arg1 (C-terminal)  
TA303210 (1 ug/ml) staining of Mouse Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arginase-1 (C-term) antibody

  Goat Anti-Arginase I Antibody  
TA305800 (0.03 ug/ml) staining of Pig (A), Mouse (B) and Rat (C) Liver lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arginase-1 antibody

  Rabbit polyclonal ARG1 antibody  
Western blot analysis of extracts from 293 cells and A549 cells, using ARG1antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Arginase-1 antibody

  Rabbit anti-ARG1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ARG1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arginase-1 antibody

  Rabbit Polyclonal Anti-ARG1 Antibody  
WB Suggested Anti-ARG1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ye P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Arginase-1 antibody

  Rabbit Polyclonal Anti-ARG1 Antibody  
WB Suggested Anti-ARG1 Antibody Titration: 5.0 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arginase-1 antibody

  Rabbit Polyclonal Anti-ARG1 Antibody  
WB Suggested Anti-ARG1 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Gt, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arginase-1 (1-145) antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Por, Rb, Rt P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Arginase-1 antibody

Arginase-1 Mouse IgG1 6G3 Purified Hu E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Arginase-1 antibody

Arginase-1 Rabbit Serum Bov E, IP, WB
2 ml / €1,180.00
  Acris Antibodies GmbH

Arginase-1 antibody

Arginase-1 Rabbit IgG Azide Free Bov Dot, E, ICC/IF, ID, IP, R, WB
10 mg / €240.00
  Acris Antibodies GmbH

Arginase-1 antibody

Arginase-1 Rabbit IgG Biotin Bov Dot, E, ICC/IF, ID, IP, R, WB
1 ml / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ARG1 - human gene knockout kit via CRISPR

ARG1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ARG1 - human gene knockout kit via CRISPR

ARG1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Arginase-1

  Recombinant protein of human arginase, liver (ARG1)  
Arginase-1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Arginase-1 (1-322, His-tag)

Recombinant human ARG1, 1-322 aa, His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

Arginase-1 (1-322, His-tag)

Recombinant human ARG1, 1-322 aa, His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

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