Alternative names for ARHGAP39 antibody
Rho GTPase-activating protein 39, KIAA1688
Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)
Background of ARHGAP39 antibody
ARHGAP39 Antibody: Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins. ARHGAP39 (Rho GTPase activating protein 39) is a 1, 083 amino acid nuclear protein that contains one MyTH4 domain, one Rho GAP domain and two WW domains. It is encoded by a gene located on human chromosome 8, which is associated with a variety of diseases and maligncies. ARHGAP39 regulates robo sigling and plays important roles in axon guidance.
Hu H, Li M, Labrador JP, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc. Natl. Acad. Sci. USA 2005; 102:4613-8.